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272264

Sigma-Aldrich

1-(3-Aminopropyl)imidazole

≥97%

Synonym(s):

1-(3-Aminopropanyl)imidazole, 3-(1-Imidazolyl)propylamine, 3-(1H-Imidazol-1-yl)propylamine, 3-(Imidazol-1-yl)propylamine, N-(3-Aminopropyl)imidazole, N-[3-(1H-Imidazol-1-yl)propyl]amine

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About This Item

Empirical Formula (Hill Notation):
C6H11N3
CAS Number:
5036-48-6
Molecular Weight:
125.17
EC Number:
225-730-9
MDL number:
MFCD00009819
UNSPSC Code:
12352005
PubChem Substance ID:
24856463
NACRES:
NA.22

assay

≥97%

form

liquid

refractive index

n20/D 1.519 (lit.)

density

1.049 g/mL at 25 °C (lit.)

functional group

amine

SMILES string

NCCCn1ccnc1

InChI

1S/C6H11N3/c7-2-1-4-9-5-3-8-6-9/h3,5-6H,1-2,4,7H2

Inchi Key

KDHWOCLBMVSZPG-UHFFFAOYSA-N

Application

1-(3-Aminopropyl)imidazole was used in the synthesis of pH-sensitive polyaspartamide derivatives. It was also used in the preparation of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution by graft reaction.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 2

flash_point_f

309.2 °F

flash_point_c

154 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF4196V
WXBF2123V
WXBF1304V
WXBD9042V
MKCR1932

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Sigma-Aldrich

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Taehoon Sim et al.
Pharmaceutics, 12(9) (2020-09-06)
Combination therapy is considered to be a promising strategy for improving the therapeutic efficiency of cancer treatment. In this study, an on-demand pH-sensitive nanocluster (NC) system was prepared by the encapsulation of gold nanorods (AuNR) and doxorubicin (DOX) by a
Xiaodan Li et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 12-21 (2017-05-22)
Photodynamic therapy (PDT) efficacy is limited by the very short half-life and limited diffusion radius of singlet oxygen (
Kwangwon Seo et al.
Macromolecular bioscience, 6(9), 758-766 (2006-09-13)
New pH-sensitive polyaspartamide derivatives were synthesized by grafting 1-(3-aminopropyl)imidazole and/or O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) 5000 on polysuccinimide for application in intracellular drug delivery systems. The DS of 1-(3-aminopropyl)imidazole was adjusted by the feed molar ratio, and the structure of the prepared polymer
Di Lu et al.
AAPS PharmSciTech (2018-06-20)
The complex design of multifunctional nanomedicine is beneficial to overcome the multiple biological barriers of drug delivery, but it also presents additional hurdles to clinical translation (e.g., scaling-up and quality control). To address this dilemma, we employed a simple imidazole-bearing
Yuwaporn Pinyakit et al.
Journal of materials chemistry. B, 8(3), 454-464 (2019-12-14)
Recently, pH-responsive polymeric micelles have gained significant attention as effective carriers for anti-cancer drug delivery. Herein, pH-responsive polymeric micelles were constructed by a simple post-polymerization modification of a single homopolymer, poly(pentafluorophenyl acrylate) (PPFPA). The PPFPA was first subjected to modification
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