466964

4′-Fluoro-2′-hydroxyacetophenone

98%

• Linear Formula: FC₆H₃(OH)COCH₃
• CAS Number: 1481-27-2
• Molecular Weight: 154.14
• MDL number: MFCD00143203
• UNSPSC Code: 12352100
• PubChem Substance ID: 24870373
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• mp: 31-35 °C (lit.)
• SMILES string: CC(=O)c1ccc(F)cc1O
• InChI: 1S/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
• InChI key: HLTBTUXAMVOKIH-UHFFFAOYSA-N

Description

General description

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P2₁/n.

Application

4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

Used recently in the preparation of medicinally active benzo[b]furans and thiophenes.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• wgk_germany: WGK 3
• flash_point_f: closed cup
• flash_point_c: closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves