474606

(S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II)

• Synonym(s): (S,S)-Co(salen), (S,S)-Jacobsen HKR catalyst
• Linear Formula: [[[(CH₃)₃C]₂C₆H₂-2-(O-)CH=N]₂C₆H₁₀]Co
• CAS Number: 188264-84-8
• Molecular Weight: 603.74
• NACRES: NA.22
• PubChem Substance ID: 24871025
• UNSPSC Code: 12352001
• MDL number: MFCD01631278

Properties

• mp: >350 °C (lit.)
• Quality Level: 200
• SMILES string: CC(C)(C)c1cc2C=[N@@H]3[C@H]4CCCC[C@@H]4[N@H]5=Cc6cc(cc(c6O[Co]35Oc2c(c1)C(C)(C)C)C(C)(C)C)C(C)(C)C
• InChI: 1S/C36H54N2O2.Co/c1-33(2,3)25-17-23(31(39)27(19-25)35(7,8)9)21-37-29-15-13-14-16-30(29)38-22-24-18-26(34(4,5)6)20-28(32(24)40)36(10,11)12;/h17-22,29-30,39-40H,13-16H2,1-12H3;/q;+2/p-2/b37-21+,38-22+;/t29-,30-;/m0./s1
• InChI key: ZFWPDJKMASHRPT-IKKUFEJKSA-L

Description

Application

(S,S)-(+)-N,N′-Bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminocobalt(II) may be used as a catalyst for the Jacobsen′s hydrolytic kinetic resolution of racemic epoxides, which is a key step during the multi-step synthesis of (+)-patulolide C, macrosphelides(I and G), (-)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid, dodoneine, epidodoneine and protein kinase C epsilon (PKCe) inhibitors.

Catalyst for the hydrolytic kinetic resolution of terminal epoxides and the enantioselective ring opening of meso epoxides.

Legal Information

Sold under license from Sterling Pharma Solutions Limited.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves