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PAMAM dendrimer, ethylenediamine core, generation 5.0 solution

5 wt. % in methanol

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Synonym(s):
Poly(amidoamine)
Linear Formula:
[NH2(CH2)2NH2]:(G=5);dendri PAMAM(NH2)128
CAS Number:
Molecular Weight:
28824.81
MDL number:
NACRES:
NA.23

description

amino surface groups

form

liquid

mol wt

generation 5.0

feature

core type ethylenediamine core (2-carbon core)

concentration

5 wt. % in methanol

no. Surface Groups

128

density

0.797 g/mL at 25 °C

storage temp.

2-8°C

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vibrant-m

412368

PAMAM dendrimer

density

0.797 g/mL at 25 °C

density

0.854 g/mL at 25 °C

density

0.806 g/mL at 25 °C

density

0.863 g/mL at 25 °C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

description

amino surface groups

description

amino surface groups

description

amino surface groups

description

amino surface groups

mol wt

generation 5.0

mol wt

generation 0.0

mol wt

generation 6.0

mol wt

generation 3.0

feature

core type ethylenediamine core (2-carbon core)

feature

core type ethylenediamine core (2-carbon core)

feature

core type ethylenediamine core (2-carbon core)

feature

core type ethylenediamine core (2-carbon core)

General description

PAMAM dendrimers are water-soluble, non-immunogenic, and biocompatible symmetrical polymers. They possess a large quantity of modifiable terminal functional groups that can bind to various targeting or guest molecules. These terminal groups are used to covalently attach drugs, targeting ligands, or imaging agents for targeted delivery, controlled release, or imaging applications.

Physical form

Contains 128 surface primary amino groups.

Legal Information

Manufactured by Dendritech®, Inc.
Dendritech is a registered trademark of Dendritech, Inc.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

49.5 °F - closed cup - Methanol

flash_point_c

9.7 °C - closed cup - Methanol


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The effect of PAMAM dendrimer generation size and surface functional group on the aqueous solubility of nifedipine
Bharathi Devarakonda, et al.
International Journal of Pharmaceutics, 284, 133-140 (2004)
Zhao-Jun Liu et al.
PloS one, 11(4), e0154053-e0154053 (2016-04-23)
Stem cell therapy has emerged as a promising approach for treatment of a number of diseases, including delayed and non-healing wounds. However, targeted systemic delivery of therapeutic cells to the dysfunctional tissues remains one formidable challenge. Herein, we present a
Catriona H Edwards et al.
Scientific reports, 10(1), 12422-12422 (2020-07-28)
In this study, the use of dendrimer-coated carbon nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum. Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PAMAM-CNTs) did not affect T. castaneum larval mortality. Expression of
Drug release characteristics of PAMAM dendrimer?drug conjugates with different linkers
Yunus E. Kurtoglu, et al.
International Journal of Pharmaceutics, 384, 189-194 (2010)
Roberta Risoluti et al.
Journal of pharmaceutical analysis, 10(4), 351-355 (2020-09-15)
In this work, functionalized carbon nanotubes (CNTs) using two polyamine polymers, polyethyleneimine (PEI) and polyamidoamine dendrimer (PAMAM), were investigated by thermal analysis in order to address preparation strategies to obtain low cytotoxic compounds with the ability to conjugate microRNAs and

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