595675

2-Bromo-5-fluoropyridine

97%

• Empirical Formula (Hill Notation): C₅H₃BrFN
• CAS Number: 41404-58-4
• Molecular Weight: 175.99
• MDL number: MFCD00234011
• UNSPSC Code: 12352100
• PubChem Substance ID: 24881597
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• bp: 80-83 °C/44 mmHg (lit.)
• mp: 30-31 °C (lit.)
• SMILES string: Fc1ccc(Br)nc1
• InChI: 1S/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H
• InChI key: UODINHBLNPPDPD-UHFFFAOYSA-N

Description

Application

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

• 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
• 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid

It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 163.4 °F - closed cup
• flash_point_c: 73 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves