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64046

Sigma-Aldrich

2,3-Dimercapto-1-propanol

≥98% (iodometric)

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Synonym(s):
BAL, British anti-Lewisite, DMP, Dimercaprol, Dithioglycerol
Linear Formula:
HOCH2CH(SH)CH2SH
CAS Number:
Molecular Weight:
124.23
Beilstein:
1732058
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Assay

≥98% (iodometric)

refractive index

n20/D 1.572-1.574
n20/D 1.573 (lit.)

bp

120 °C/15 mmHg (lit.)

density

1.239 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

OCC(S)CS

InChI

1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

InChI key

WQABCVAJNWAXTE-UHFFFAOYSA-N

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This Item
T58203W508500282413
Dimethyl phthalate ≥99%

Sigma-Aldrich

W508500

Dimethyl phthalate

refractive index

n20/D 1.572-1.574, n20/D 1.573 (lit.)

refractive index

n20/D 1.516 (lit.)

refractive index

n20/D 1.515 (lit.)

refractive index

n20/D 1.495 (lit.)

bp

120 °C/15 mmHg (lit.)

bp

130-135 °C/1 mmHg (lit.)

bp

282 °C (lit.)

bp

156-160 °C/0.15 mmHg (lit.)

density

1.239 g/mL at 25 °C (lit.)

density

0.969 g/mL at 25 °C (lit.)

density

1.19 g/mL at 25 °C (lit.)

density

1.083 g/mL at 25 °C (lit.)

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

200

Quality Level

200

Quality Level

400

Quality Level

100

General description

Dimercapto-1-propanol acts as a chelating agent and forms stable complexes with certain heavy metals, including arsenic, mercury, and lead.

Application

2,3-Dimercapto-1-propanol has been used in synthesizing novel (2-substituted phenyl-1,3-dithiolan-4-yl) methanol (PDTM) derivatives, which are potent tyrosinase inhibitors. It can also be considered for developing new drugs against AIDS due to its ability to inhibit HIV-1 tat activity.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

233.6 °F - closed cup

Flash Point(C)

112 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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S Kubota et al.
AIDS research and human retroviruses, 6(7), 919-927 (1990-07-01)
We have examined the effect of 2,3 dimercapto-1-propanol (DMP), which is known as an anti-heavy metal-poisoning drug, against human immunodeficiency virus type 1 (HIV-1). We demonstrate that DMP inhibited transactivation directed by tat protein, which is a metal containing transcriptional
Metal chelators and neurotoxicity: lead, mercury, and arsenic
Bjorklund G, et al.
Archives of Toxicology, 91(12), 3787-3797 (2017)
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American journal of physiology. Lung cellular and molecular physiology, 307(12), L948-L958 (2014-10-12)
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Strict definition of invasive aspergillosis (IA) cases is required to allow precise conclusions about the efficacy of antifungal therapy. The Global Comparative Aspergillus Study (GCAS) compared voriconazole to amphotericin B (AmB) deoxycholate for the primary therapy of IA. Because predefined

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