656984

Isopropylmagnesium chloride lithium chloride complex solution

1.3 M in THF

• Synonym(s): Turbo Grignard
• Linear Formula: (CH₃)₂CHMgCl · LiCl
• Molecular Weight: 145.24
• MDL number: MFCD07784514
• UNSPSC Code: 12352103
• PubChem Substance ID: 24884252
• NACRES: NA.22

Properties

• reaction suitability: reaction type: Grignard Reaction
• Quality Level: 100; 200
• concentration: 1.3 M in THF
• density: 0.951 g/mL at 25 °C
• SMILES string: [Li]Cl.CC(C)[Mg]Cl
• InChI: 1S/C3H7.2ClH.Li.Mg/c1-3-2;;;;/h3H,1-2H3;2*1H;;/q;;;2*+1/p-2
• InChI key: CWTUREABAILGIK-UHFFFAOYSA-L

Description

Application

Reagent for Selective Metalations

Used for:

• Preparation of functionalized acyclic alkenyl magnesium reagents/preparation of 1,2-diketones
• Preparation of cyclic alkenyl and dienyl magnesium reagents
• Preparation of functionalized triazenes/preparation of carbazoles
• Regioselective functionalization of trisubstituted pyridines
• Electrophilic amination for preparation of amines
• Preparation of Grignards reagents in the presence of masked ketones and aldehydes (using readily deprotectable silylated cyanohydrins)
• Preparation of Benzylic Grignards via Sulfur-Magnesium exchange
• Functionalization via I-Mg Exchange of unprotected aromatic and heteroaromatic carboxylic acids
• Functionalization via I-Mg Exchange of unprotected imidazoles
• Pyridyne formation
• Functionalization of cyclopentene derivatives
• Preparation of 2,3-functionalized furans, benzofurans, and thiophenes
• Stereoselective synthesis of substituted cyclopropanes

Reagent used with CH₃MgCl/LiCl to affect magnesium-halogen exchange on unprotected aryl carboxylic acids.

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Product of Albemarle US Inc

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H314,H335,H336,H351
• pcodes: P202 - P210 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
• target_organs: Central nervous system, Respiratory system
• supp_hazards: EUH014,EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 1.4 °F
• flash_point_c: -17 °C
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter