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Sigma-Aldrich

Poly(ethylene glycol) dithiol

average Mn 3,400

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Synonym(s):
PEG dithiol
Linear Formula:
HSCH2CH2(OCH2CH2)nSH
NACRES:
NA.23

form

powder

mol wt

average Mn 3,400

reaction suitability

reagent type: cross-linking reagent
reactivity: thiol reactive

mp

58-65 °C

Ω-end

thiol

α-end

thiol

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

−20°C

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This Item
704369729108757799
mol wt

average Mn 3,400

mol wt

Mn 1200-1800, average Mn 1,500

mol wt

average Mn 800

mol wt

PEG average Mn 3,400 (n ~ 77), average Mn 3,800

reaction suitability

reagent type: cross-linking reagent
reactivity: thiol reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: thiol reactive

reaction suitability

reagent type: chemical modification reagent
reactivity: thiol reactive

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

mp

58-65 °C

mp

47-50 °C

mp

-

mp

45-53 °C

Ω-end

thiol

Ω-end

thiol

Ω-end

thiol

Ω-end

NHS ester

α-end

thiol

α-end

thiol

α-end

methoxy

α-end

biotin

Other Notes

Molecular weight: Mn 3,060-3,740

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Highlighting new synthetic modifications of PEG to improve the mechanical properties and degradation of resulting hydrogels in tissue engineering applications.

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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