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725765

Sigma-Aldrich

2-Methyl-4-isothiazolin-3-one

95%

Synonym(s):

2-Methyl-3(2H)-isothiazolone

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About This Item

Empirical Formula (Hill Notation):
C4H5NOS
CAS Number:
2682-20-4
Molecular Weight:
115.15
Beilstein/REAXYS Number:
606203
EC Number:
220-239-6
MDL number:
MFCD01742315
UNSPSC Code:
12352100
PubChem Substance ID:
329764182
NACRES:
NA.21

Quality Level

100

assay

≥94.0% (GC)
95%

form

lumps

impurities

≤5% water

SMILES string

CN1SC=CC1=O

InChI

1S/C4H5NOS/c1-5-4(6)2-3-7-5/h2-3H,1H3

InChI key

BEGLCMHJXHIJLR-UHFFFAOYSA-N

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Application

  • Insights into the mechanisms of within-species variation in sensitivity to chemicals: A case study using daphnids exposed to CMIT/MIT biocide.: This study investigates the differential sensitivity of daphnids to 2-Methyl-4-isothiazolin-3-one, highlighting the biochemical mechanisms underlying these variations. The findings provide crucial insights for environmental safety assessments (Kim et al., 2023).
  • Effects of the biocide methylisothiazolinone on Xenopus laevis wound healing and tail regeneration.: The study assesses the impact of 2-Methyl-4-isothiazolin-3-one on regenerative processes in amphibians, contributing to the understanding of its biological effects and potential toxicity (Delos Santos et al., 2016).
  • T cell lymphomatoid contact dermatitis: a challenging case and review of the literature.: This review includes discussions on 2-Methyl-4-isothiazolin-3-one-induced contact dermatitis, providing valuable information for dermatological applications and safety assessments (Knackstedt and Zug, 2015).

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A

supp_hazards

EUH071

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3025
BCCN1555
BCCM9076
BCCM7270
BCCG6210

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Eleanor Higgins et al.
Dermatitis : contact, atopic, occupational, drug, 24(2), 73-76 (2013-03-12)
The isothiazolinones methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) are the active ingredients in a frequently used preservative in cosmetic, household, and industrial products. This study reviewed our department's cases of allergic contact dermatitis caused by MCI/MI, outlining their clinical presentation and possible
A Spawn et al.
Neuroscience, 205, 194-204 (2012-01-17)
Methylisothiazolinone (MIT) is a commonly used biocide known to be neurotoxic in vitro. Brief exposure of cortical neurons in culture to MIT results in increased neurodegeneration, whereas chronic exposure of developing neurons in culture to low concentrations of MIT has
Christina L Burnett et al.
International journal of toxicology, 29(4 Suppl), 187S-213S (2010-07-22)
Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MIT is a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble
Leena Ackermann et al.
Contact dermatitis, 64(1), 49-53 (2010-12-21)
Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products.
Julien Mutschler et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(3), 439-446 (2009-05-16)
Assessment of skin sensitization hazard of chemicals currently depends on in vivo methods. Considering the forthcoming European Union ban on in vivo testing of cosmetic/toiletry ingredients, the search for alternative non-animal approaches is an urgent challenge for investigators today. For
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