Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

764221

Sigma-Aldrich

Propargyl-N-hydroxysuccinimidyl ester

Synonym(s):

2,5-Dioxopyrrolidin-1-yl 3-(prop-2-ynyloxy)propanoate, 3-(2-Propyn-1-yloxy)propanoic acid 2,5-dioxo-1-pyrrolidinyl ester, Alkyne-NHS ester, Propargyl-succinimidyl-ester

Sign Into View Organizational & Contract Pricing

Select a Size

50 MG
$86.77
250 MG
$292.00

$86.77

List price$93.70Save 7%
Web-Only Promotion

Available to ship onApril 09, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
50 MG
$86.77
250 MG
$292.00

About This Item

Empirical Formula (Hill Notation):
C10H11NO5
CAS Number:
1174157-65-3
Molecular Weight:
225.20
MDL number:
MFCD13184973
UNSPSC Code:
12352108
PubChem Substance ID:
329767108
NACRES:
NA.22

$86.77

List price$93.70Save 7%
Web-Only Promotion

Available to ship onApril 09, 2025Details

Request a Bulk Order

form

solid

Quality Level

100

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

mp

36-41 °C

functional group

NHS ester
alkyne

storage temp.

−20°C

SMILES string

C#CCOCCC(ON1C(CCC1=O)=O)=O

InChI

1S/C10H11NO5/c1-2-6-15-7-5-10(14)16-11-8(12)3-4-9(11)13/h1H,3-7H2

InChI key

WKIKHHMUNOVQLD-UHFFFAOYSA-N

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
792047633259QBD10260
Propargyl-N-hydroxysuccinimidyl ester

764221

Propargyl-N-hydroxysuccinimidyl ester

2-Bromoisobutanoic acid N-hydroxysuccinimide ester 98% (GC)

792047

2-Bromoisobutanoic acid N-hydroxysuccinimide ester

N-Acetoxy-d3-succinimide 98 atom % D

633259

N-Acetoxy-d3-succinimide

m-dPEG®8-NHS ester

QBD10260

m-dPEG®8-NHS ester

form

solid

form

liquid

form

solid

form

solid or viscous liquid

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

mp

36-41 °C

mp

135-140 °C

mp

133 °C (lit.)

mp

-

reaction suitability

reaction type: click chemistry

reaction suitability

-

reaction suitability

-

reaction suitability

-

functional group

NHS ester

functional group

-

functional group

-

functional group

-

Application

Propargyl-N-hydroxysuccinimidyl ester may be used as a tool for identifying nucleophilic ligandable hotspots by chemoproteomic approaches.[1]
Propargyl-NHS ester is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc, with a terminal alkyne. The alkyne can be reacted with an azide containing compound or biomolecule via copper catalyzed azide-alkyne click chemistry to yield a stable triazole linkage.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCV8069
    MKCT7888
    MKCS3340
    MKCP4752
    MKCN7690

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Qianyun Zhang et al.
    ACS nano, 12(10), 10473-10485 (2018-10-06)
    Multivalent presentation of ligands on nanoparticles (NPs) is considered a general strategy for enhancing receptor binding and activation through amplification of ligand-receptor interactions within the footprint of the individual NPs. The spatial clustering of ligand-functionalized NPs represents an additional, less
    Activatable T1 Relaxivity Recovery Nanoconjugates for Kinetic and Sensitive Analysis of Matrix Metalloprotease
    Zhu X, et al.
    ACS Applied Materials & Interfaces (2017)
    NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots.
    Ward CC, et al.
    ACS Chemical Biology (2017)
    Yi Yu et al.
    Nature chemical biology, 16(4), 387-390 (2019-12-25)
    Here, we report a rapid CRISPR-Cas9-mediated gene knock-in strategy that uses Cas9 ribonucleoprotein and 5'-modified double-stranded DNA donors with 50-base-pair homology arms and achieved unprecedented 65/40% knock-in rates for 0.7/2.5 kilobase inserts, respectively, in human embryonic kidney 293T cells. The identified

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service