All Photos(1)




Thiol poly(ethylene glycol)-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA average Mn 15,000, lactide:glycolide 50:50

Sign Into View Organizational & Contract Pricing

Thiol-PEG-b-PLGA, Thiol-PEG-PLGA
Linear Formula:


Identity: Conforms to structure



feed ratio

lactide:glycolide 50:50
lactide:glycolide 50:50±5 (by NMR)

mol wt

PEG Mn 4000-6000  g/mol (by NMR)
PEG average Mn 5,000
PLGA Mn 13500-16500 g/mol (by NMR)
PLGA average Mn 15,000



storage temp.


Related Categories


Thiol poly(ethylene glycol)-block-poly(lactide-co-glycolide) is a thiol-functionalized, biocompatible, amphiphilic block copolymer. Due to its self-assembling properties, this material can be used in the formation of nanoparticles for drug delivery. Additionally, due to the thiol-functionalization of the PEG block, this material can be used to rapidly covalently conjugate biomolecules, API, or targeting ligands. Potential uses include the targeted and/or controlled release of cancer drugs, anti-inflammatory drugs, antibiotics, or anaesthetic agents.

Storage Class

11 - Combustible Solids




Not applicable


Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).


Product Number
Pack Size/Quantity

Additional examples:





enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties and nanomedical applications as drug delivery system
Locatelli E, et al
Journal of Nanoparticle Research, 14, 1316-1316 (2012)
Ilaria Monaco et al.
Journal of medicinal chemistry, 60(10), 4510-4516 (2017-05-05)
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high
Yihan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 105(6), 1692-1716 (2016-04-22)
Poly (lactic-co-glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service