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Folate-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 50:50

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Synonym(s):
Biotin-PEG-PLGA, Polyethylene glycol
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC25H29N11O8

form

powder or chunks

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 2,000 (by NMR)
PLGA average Mn 10,000 (by NMR)

color

white to tan

storage temp.

−20°C

Related Categories

Application

Folate-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The folate functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Articles

Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.

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