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919012

Sigma-Aldrich

PEI Prime™ linear polyethylenimine

suitable for gene delivery

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Synonym(s):
PEI
Linear Formula:
(C2H5N . HCl)n
CAS Number:
49553-93-7
MDL number:
MFCD00009361

Quality Level

100

form

powder

color

white to off-white

storage temp.

2-8°C

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764604765090764582
PEI Prime™ linear polyethylenimine suitable for gene delivery

Sigma-Aldrich

919012

PEI Prime™ linear polyethylenimine

Polyethylenimine, linear average Mn 2100, PDI <1.3

Sigma-Aldrich

764604

Polyethylenimine, linear

Polyethylenimine, linear average Mn 10,000, PDI ≤1.3

Sigma-Aldrich

765090

Polyethylenimine, linear

Polyethylenimine, linear average Mn 5,000, PDI ≤1.3

Sigma-Aldrich

764582

Polyethylenimine, linear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

color

white to off-white

color

-

color

-

color

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

Application

PEI Prime™ is a cationic polymer designed for high-yield, reproducible and scalable drug and gene delivery. As a gene carrier, PEI forms a complex with nucleic acids via electrostatic self-assembly between the negatively charged nucleic acid phosphate groups and positively charged PEI amine groups. Due to this interaction, PEI has been extensively explored as a gene carrier and is one of the most effective synthetic polymers for the delivery of nucleic acids into cells through endocytosis.


PEI Prime™ uses an optimized form of PEI to reduce performance variance and speed process development time. Each batch of PEI Prime™ undergoes triplicate, quantitative performance testing using an SEAP reporter assay. PEI Prime™ is an excellent choice to produce any biologic cost-effectively, including recombinant proteins, antibodies, and viruses.

Legal Information

PEI Prime is a trademark of Serochem LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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S M Zou et al.
The journal of gene medicine, 2(2), 128-134 (2000-05-16)
Several nonviral vectors including linear polyethylenimine (L-PEI) confer a pronounced lung tropism to plasmid DNA when injected into the mouse tail vein in a nonionic solution. and results We have optimized this route by injecting 50 microg DNA with excess
L Wightman et al.
The journal of gene medicine, 3(4), 362-372 (2001-09-01)
Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Linear or branched polyethylenimine (PEI)/DNA complexes were generated in varying
W T Godbey et al.
Biomaterials, 22(5), 471-480 (2001-02-24)
Poly(ethylenimine) (PEI) was used to transfect the endothelial cell line EA.hy 926, and the secreted levels of three gene products, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand Factor (vWF), were assessed via ELISA. We

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