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Droplet generator chip - Droplet size variation

Fluidic 947, COC

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Microfluidic chip, Microparticle synthesis, Nanoparticle


Microfludic chip x1


Microfluidic generation of droplets can produce highly monodispersed droplets with high frequency (up to hundreds of kHz). Interest in droplet-based microfluidic systems has grown substantially, because microfluidics offers the ability to handle very small volumes (μl to fl) of fluids, provides better mixing, encapsulation, sorting, and sensing. Microfluidics can be used for high throughput experimentation. Microfluidic-based droplets have many diverse and varied applications such as particle synthesis and chemical analysis. Highly controlled droplet production also makes single cell analysis, or drug testing possible.

Droplet generator chip - Droplet size variation, Fluidic 947, COC is made of COC (Cyclic olefin copolymer). The microfluidic chip Fluidic 947 features eight flow focusing droplet generator units to evaluate the formation of various droplet sizes. This chip accommodates the smallest nozzle size, as little as 10 μm and works well for experiments that require droplets with small dimensions and volumes. The inlet channels for both continuous and disperse phase are designed to enable stable droplet generation with a certain degree of flow restriction.

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Recent advances of controlled drug delivery using microfluidic platforms.
Li X, et al.
Advanced Drug Delivery Reviews, 128, 3-28 (2018)
Microfluidic-assisted fabrication of carriers for controlled drug delivery.
Santos H A, et al.
Lab on a chip, 17, 1856-1883 (2017)
Recent advances of controlled drug delivery usingmicrofluidic platforms.
Li X, et al.
Advanced Drug Delivery Reviews, 128, 3-28 (2018)


Microfluidic assembly can efficiently overcome the general disadvantages of polyamine nanoencapsulation of nucleic acids, such as a less defined morphology and composition, polydispersity, and poor reproducibility.

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