923311

4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid

• Synonym(s): Rigid linker for PROTAC^® development
• Empirical Formula (Hill Notation): C₁₇H₂₂N₂O₅
• Molecular Weight: 334.37
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• form: powder
• Quality Level: 100
• reaction suitability: reagent type: linker
• functional group: Boc; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: OC(C1=CC(OC2CC3(C2)CN(C(OC(C)(C)C)=O)C3)=CC=N1)=O
• InChI: 1S/C17H22N2O5/c1-16(2,3)24-15(22)19-9-17(10-19)7-12(8-17)23-11-4-5-18-13(6-11)14(20)21/h4-6,12H,7-10H2,1-3H3,(H,20,21)

Description

Application

4-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)picolinic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
923338
923370
923419
923346
923427

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable