B29806

1-Benzyl-4-piperidone

99%

• Synonym(s): 1-Benzyl-4-oxopiperidine
• Empirical Formula (Hill Notation): C₁₂H₁₅NO
• CAS Number: 3612-20-2
• Molecular Weight: 189.25
• Beilstein/REAXYS Number: 128556
• EC Number: 222-782-4
• MDL number: MFCD00006192
• UNSPSC Code: 12352100
• PubChem Substance ID: 24891676
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99%
• form: liquid
• refractive index: n20/D 1.541 (lit.)
• bp: 134 °C/7 mmHg (lit.)
• density: 1.021 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: O=C1CCN(CC1)Cc2ccccc2
• InChI: 1S/C12H15NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2
• InChI key: SJZKULRDWHPHGG-UHFFFAOYSA-N

Description

General description

1-Benzyl-4-piperidone serves as a versatile heterocyclic building block in the synthesis of pharmaceutical compounds.

Application

1-Benzyl-4-piperidone is generally used as a building block in the synthesis of various medicinal compounds. Applications include the synthesis of:

• Spirocyclic furopyridines as haloperidol-sensitive σ receptor ligands.
• Multi-target-directed donepezil + propargylamine + 8-hydroxyquinoline (DPH) hybrids for the treatment of Alzheimer′s disease.
• Spiropiperidine iminohydantoin aspartyl protease inhibitors.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 159.8 °F
• flash_point_c: 71 °C
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter