E50000

Ethyl trifluoroacetate

99%

• Synonym(s): Trifluoroacetic acid ethyl ester
• Linear Formula: CF₃COOC₂H₅
• CAS Number: 383-63-1
• Molecular Weight: 142.08
• Beilstein/REAXYS Number: 1761411
• EC Number: 206-851-6
• MDL number: MFCD00000419
• UNSPSC Code: 12352100
• PubChem Substance ID: 24894596
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99%
• form: liquid
• refractive index: n20/D 1.307 (lit.)
• bp: 60-62 °C (lit.)
• density: 1.194 g/mL at 25 °C (lit.)
• SMILES string: CCOC(=O)C(F)(F)F
• InChI: 1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
• InChI key: STSCVKRWJPWALQ-UHFFFAOYSA-N

Description

Application

Ethyl trifluoroacetate can be used:

• To synthesize cyclopentenones or furans containing trifluoromethyl group from aromatic ynones.
• In the selective trifluoroacetylation of anilines catalyzed by 4-dimethylaminopyridine.
• As a starting material in the two-step electrosynthesis of trifluoroacetyltrimethylsilane (CF₃COSiMe₃).
• In the preparation of trifluoromethyl ketones via trifluoroacetic ester/ketone metathesis with alkyl aryl ketones.
• To synthesize o-fluorinated trifluoro acetophenones from substituted fluorobenzene.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302,H315,H318,H335
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 30.2 °F - closed cup
• flash_point_c: -1 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves