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KITALYSIS-CN

Sigma-Aldrich

KitAlysis High-Throughput Buchwald-Hartwig Amination Reaction Screening Kit-Pack of 4

Synonym(s):

Amination Screening Kit, Buchwald-Hartwig Amination

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.22

reaction suitability

reaction type: Buchwald-Hartwig Amination
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reagent type: catalyst
core: palladium

storage temp.

room temp

General description

The KitAlysis High Throughput Buchwald–Hartwig Amination Reaction Screening Kit enables chemists to quickly and efficiently screen Buchwald–Hartwig C–N cross-coupling reaction conditions. Quick identification of optimal conditions allows faster scale-up of the synthetic reaction. All required chemicals come pre-weighed for ease of use. A step-by-step user guide and experimental excel sheets are available for download to facilitate the process.

Application

There are four possible screens that can be run based upon the user’s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.

Two Solvents, Weak Base (Cs2CO3)
Download the experimental excel file here
Two Solvents, Strong Base (NaOt-Bu)
Download the experimental excel file here
One Solvent (Dioxane), Two Bases
Download the experimental excel file here
One Solvent (DMAc), Two Bases
Download the experimental excel file here

Each kit contains 4 screening sets that contain the following:
Each customizable screening kit contains



  • 12 X 2 pre-weighed catalysts (1 μmol) in individual microvials with magnetic stir bars
  • 2 bases (NaOt-Bu and Cs2CO3)
  • 2 degassed anhydrous solvents (dioxane and DMAc) in ampules
  • 2 substrate reaction vials with stir bars
  • 1 internal standard
  • 4 reaction block replacement films
Monitor reaction progress via TLC-MS by following this protocol

Best when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

  • Designed and tested by synthetic chemists
  • Easily run 24-microscale reaction in parallel
  • 10 μmol reactions with 1 μmol catalyst, 3 equiv. base, 0.1 M concentration
  • Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC

Kit Components Only

Product No.
Description

  • SnapIT Ampule Opener, Regular, for 1-2ml, 5-10ml, 10-15ml ampoules 1 EA

Kit Components Also Available Separately

Product No.
Description
SDS

  • 900634N,N-Dimethylacetamide, anhydrous, ZerO2®, 99.8% 8 mLSDS

  • 9006401,4-Dioxane, anhydrous, ZerO2®, 99.8% 8 mLSDS

  • 702706Sodium tert-butoxide solution, 2 M in THF, ZerO2® 4 mLSDS

  • 747130Josiphos SL-J009-1 Pd G3 5 µmolSDS

  • 753009SPhos Pd G2 5 µmolSDS

  • 753246RuPhos Pd G2 5 µmolSDS

  • 756482P(t-Bu)3 Pd G2 5 µmolSDS

  • 761605BrettPhos Pd G3, 98% 5 µmolSDS

  • 762229tBuXPhos Pd G3, 98% 5 µmolSDS

  • 763004CPhos Pd G3, 95% 5 µmolSDS

  • 763039XantPhos Pd G3, 95% 5 µmolSDS

  • 763381XPhos Pd G3, 98%, 1:1 MTBE adduct 5 µmolSDS

  • 792357MorDalphos Pd G3 5 µmolSDS

  • 804959DavePhos-Pd-G3, 95% 5 µmolSDS

  • 804967rac-BINAP-Pd-G3, 95% 5 µmolSDS

See All (15)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Eye Dam. 1 - Repr. 1B - Self-heat. 1 - Skin Corr. 1B - STOT RE 2 Oral - STOT SE 3

target_organs

Central nervous system, Kidney,Adrenal gland,Testes, Respiratory system

supp_hazards

wgk_germany

WGK 3

flash_point_f

-4.0 °F

flash_point_c

-20 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-Throughput Experimentation in Catalysis and Materials Science.
Gordillo A, et al. et al.
Ullmann's Encyclopedia of Industrial Chemistry (2014)
Karl D Collins et al.
Nature chemistry, 6(10), 859-871 (2014-09-23)
New organic reactivity has often been discovered by happenstance. Several recent research efforts have attempted to leverage this to discover new reactions. In this Review, we attempt to unify reported approaches to reaction discovery on the basis of the practical
Scientist-Led High-Throughput Experimentation (HTE) and Its Utility in Academia and Industry.
Schmink JR, et al.
Aldrichimica Acta, 46, 71-80 (2013)
Spencer D Dreher et al.
Journal of the American Chemical Society, 130(29), 9257-9259 (2008-06-28)
Microscale parallel experimentation was used to discover three catalyst systems capable of coupling secondary organotrifluoroborates with sterically and electronically demanding aryl chlorides and bromides. The ensuing results represent the first comprehensive study of alkylboron coupling to aryl chlorides and, in

Articles

KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.

Materials Included in your KITALYSIS-24PD-2PK High-Throughput Screening Kit

Preformed catalysts in the kit are stable but become air-sensitive when activated; Schlenk technique aids scale-up.

All contents in the foil bag are weighed, plated, packed, and sealed in a glove box under nitrogen.

Protocols

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Catalyst screening kits, KitAlysis™, and TLC-MS analysis enable high-throughput synthesis and analysis for efficient reactions.

KitAlysis™ Cu C-N (Buchwald-Hartwig) cross-coupling high-throughput screening kit. Detailed Set-Up User Guide and a downloadable excel file for calculations.

Related Content

Solutions & slurries to make: Go to the online user set-up page to enter molecular weights into the downloadable excel file.

Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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