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C-108

Supelco

Cyclosporin D solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

1-(3-Chlorophenyl)piperazine-D8 hydrochloride solution

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About This Item

CAS Number:
63775-96-2
EC Number:
200-835-2
MDL number:
MFCD11111526
UNSPSC Code:
41116107
PubChem Substance ID:
329774843
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

C\C=C\C[C@@H](C)[C@@H](O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C

InChI

1S/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(14)15)63(86)74(52)25/h26-27,34-47,49-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44+,45+,46?,47+,49+,50+,51+,52+,53-/m1/s1

Inchi Key

ZNVBEWJRWHNZMK-UPMQNEEPSA-N

Related Categories

General description

An internal standard for clinical testing of Cyclosporin A by LC-MS/MS. This Certified Spiking Solution® is suitable for critical quantitative applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within Cyclosporin A′s narrow therapeutic range. The Snap-N-Spike® format allows laboratories to eliminate weighing operations of these hazardous substances, significantly reducing occupational exposure hazards related to handling of acutely toxic powders, and provides the ability to spike into their matrix of choice just before use.

Application


  • High-Performance Liquid Chromatography for Cyclosporin D: A study developed a reversed-phase high-performance liquid chromatography method for the determination of cyclosporin A in human and mouse plasma, using Cyclosporin D as internal standard, highlighting its applications in drug discovery and bioavailability studies (Bardelmeijer et al., 2001).

  • Mass Spectrometric Analysis of Cyclosporins: Research focused on the thermospray high-performance liquid chromatography/mass spectrometric determination of cyclosporins, including Cyclosporin D, contributing to advancements in the analysis of immunosuppressant drugs and their pharmacological profiling (Abián et al., 1992).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Related product

Product No.
Description
Pricing

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

Certificates of Analysis (COA)

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U Christians et al.
Clinical chemistry, 34(1), 34-39 (1988-01-01)
Using solid-phase extraction columns and "high-performance" liquid-chromatographic (HPLC) analysis, we could determine cyclosporin A and nine of its metabolites in blood, bile, and urine. To facilitate calculations of concentrations of cyclosporin A and its metabolites from the chromatograms, we used
G M Randleff-Rasmussen et al.
Transplant international : official journal of the European Society for Organ Transplantation, 2(4), 181-186 (1989-12-01)
Various methods of determining cyclosporin (CyA) levels in patients after kidney transplantation were compared. These included polyclonal antibody (pcAb-), specific and nonspecific monoclonal antibody (S- and NmcAb-) radioimmunoassays (RIA), and high performance liquid chromatography (HPLC). The results obtained by the
P J Stewart et al.
Calcified tissue international, 45(4), 222-226 (1989-10-01)
Cyclosporine A (CsA) is a potent immunosuppressive agent that inhibits stimulated bone resorption in vitro. To study the mechanism of this effect, we have compared CsA with several cyclosporine analogs that vary in immunosuppressive potency. CsA as well as another
Synergistic effects of cyclosporin analogs--A, D, G, IMM-125--with rapamycin and/or brequinar.
B D Kahan et al.
Transplantation proceedings, 26(5), 3021-3024 (1994-10-01)
K Tanaka et al.
Pharmaceutical research, 13(7), 1073-1077 (1996-07-01)
P-glycoprotein-mediated transcellular transport of anticancer agents and the inhibitory effect of cyclosporin analogs and FK506 were investigated. The transcellular transport of daunorubicin and vinblastine by monolayers of LLC-GA5-COL150 cells which overexpressed P-glycoprotein was measured in the presence and absence of
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