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D-045

Supelco

Doxylamine succinate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C21H28N2O5
CAS Number:
Molecular Weight:
388.46
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

OC(=O)CCC(O)=O.CN(C)CCOC(C)(c1ccccc1)c2ccccn2

InChI

1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

InChI key

KBAUFVUYFNWQFM-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

General description

Doxylamine is a member of the ethanolamine class of antihistamines and is the most effective over-the-counter (OTC) sedative in the US. This Snap-N-Spike® Reference Solution is applicable to use in LC/MS or GC/MS applications for clinical toxicology or forensic analysis.

Application


  • Quality assessment of doxylamine succinate: A chemometric approach was applied for quality assessment of doxylamine succinate with its degradation product, using predictive models based on UV-spectrophotometric data, highlighting its utility in ensuring the integrity of pharmaceutical formulations (Abd El-Hadi et al., 2022).

  • Analysis in over-the-counter medications: Doxylamine succinate was analyzed as part of a quaternary mixture in cold medications, utilizing a sequential spectrophotometric resolution approach, indicating its role in multi-component pharmaceutical analysis (Kelani et al., 2023).

  • LC-MS/MS method for plasma levels: A sensitive LC-MS/MS method was developed for determining doxylamine levels in human plasma, demonstrating its application in pharmacokinetic studies and bioequivalence assessments (Fu et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

wgk_germany

WGK 2

flash_point_f

49.5 °F

flash_point_c

9.7 °C


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A E Rudenko et al.
Likars'ka sprava, (2)(2), 55-59 (2003-05-31)
A positive result has been obtained in treating sleep disorders in patients with chronic vascular affections of the brain with using the drugs donormyl and sonnate-KM [symbol: see text]. Donormyl is recommended for use in sleep disturbances (not very prolonged
B S Somashekar et al.
Magnetic resonance in chemistry : MRC, 42(7), 636-640 (2004-06-08)
A protonation and dynamic structural study of doxylamine succinate, a 1:1 salt of succinic acid with dimethyl-[2-(1-phenyl-1-pyridin-2-yl-ethoxy)ethyl]amine, in solution using one- and two-dimensional 1H and 13C NMR experiments at variable temperature and concentration is presented. The two acidic protons of
C L Holder et al.
Journal of analytical toxicology, 11(3), 113-121 (1987-05-01)
Elimination and metabolic profiles of doxylamine and its nonconjugated metabolites were determined after the oral administration of [14C]-doxylamine succinate (13.3 mg/kg and 133 mg/kg doses) to male and female Fischer 344 rats. Total urine and fecal recovery of the administered
Sebastián Videla et al.
Drugs in R&D, 12(4), 217-225 (2012-12-13)
Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. The data available on the pharmacokinetic profile of doxylamine in humans are limited, notwithstanding that this drug has been marketed in European
OTC product: Zicam Cold and Flu Medicated Spoons.
Julie L Olenak
Journal of the American Pharmacists Association : JAPhA, 46(6), e52-e53 (2007-05-23)

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