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M-080

Supelco

Methylmalonic acid solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C4H6O4
CAS Number:
Molecular Weight:
118.09
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing
pharmaceutical (small molecule)

format

single component solution

storage temp.

−20°C

SMILES string

CC(C(O)=O)C(O)=O

InChI

1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)

InChI key

ZIYVHBGGAOATLY-UHFFFAOYSA-N

General description

Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution® is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS.

Application



  • Organic acid analysis for metabolic profiling: Research highlighted the integration of soil microbiota and metabolome, where methylmalonic acid was part of the metabolic profiling, revealing insights into how controlled release fertilizer impacts sugarcane growth, emphasizing the compound′s role in agricultural biotechnology (Yuan et al., 2023).


  • Vitamin B12 deficiency research: Methylmalonic acid was featured in research on the cellular mechanisms affecting the MAFB/NOTCH3 axis in osteosarcoma, where its levels could potentially reflect perturbations relevant to vitamin B12 deficiency, aiding in better understanding of disease progression (Zhang et al., 2024).


  • Methylmalonic acid standard for mass spectrometry analysis: The analysis of soybean root systems under varying nutrient conditions included methylmalonic acid as a standard in mass spectrometry to better understand nutrient uptake mechanisms, showcasing its utility in plant physiology and biochemistry studies (Qin et al., 2023).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

wgk_germany

WGK 2

flash_point_f

closed cup

flash_point_c

closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yu-peng Liu et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 50(6), 410-414 (2012-08-31)
Methylmalonic aciduria is the most common disorder of organic acidurias in the mainland of China. It is also the one of treatable metabolic disorders. The clinical spectrum of the patients varies from severe neonatal-onset forms with neonatal brain injury and
P F Schuck et al.
Free radical research, 47(3), 233-240 (2013-01-10)
Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. The disease is clinically characterized by progressive neurological deterioration and kidney failure, whose pathophysiology is still unclear. In the present work we investigated the effects of acute MMA
Setareh Shahab-Ferdows et al.
The Journal of nutrition, 142(10), 1881-1887 (2012-08-24)
A high prevalence of low serum vitamin B-12 concentrations has been reported in studies and surveys in Latin America including Mexico, but the functional consequences are unknown. This randomized controlled trial assessed the response to a high-dose vitamin B-12 supplementation
Nora Berghoff et al.
American journal of veterinary research, 74(1), 84-89 (2012-12-29)
To determine the prevalence of hypocobalaminemia or methylmalonic acidemia (or both) in dogs with chronic gastrointestinal disease. Serum samples from 56 dogs with chronic gastrointestinal disease and 43 control dogs. Serum cobalamin and methylmalonic acid (MMA) concentrations were measured in
Takayuki Watanabe et al.
Journal of feline medicine and surgery, 14(12), 942-945 (2012-08-22)
A 10-year-old domestic shorthair cat showed anorexia, lethargy and ptyalism with hyperammonaemia. Portosystemic shunts were not identified by computed tomography angiography. Biopsy results revealed mild interstinal nephritis and no lesion in the liver. Analysis of urine revealed the presence of

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