All Photos(1)




SMC® Human Phospho-Tau (T181) High Sensitivity Immunoassay Kit

Sign Into View Organizational & Contract Pricing

pTau T181 Single Molecule Counting Kit, pTau T181 immunoassay kit, pTau T181 ultra-sensitive immunoassay, pTau Thr181 immunoassay kit



assay range

sensitivity: 0.94 pg/mL
(Lower Limit of Quantification: )

inter-assay cv: ≤12%
intra-assay cv: ≤7%
(five normal plasma samples run in triplicate by 3 different operators on 3 different days.)


single molecule counting: suitable

storage temp.


General description

The SMC® Human Phospho-Tau (T181) High Sensitivity Immunoassay Kit contains all reagents required to perform the assay. This assay takes advantage of a standard immunoassay workflow configured in a standard plate format.
Assay protocols are similar to existing sandwich ELISA methods with two key differences:
1) Elution buffer disrupts the sandwich, separating the labeled detection antibody for quantification.
2) The Erenna and SMCxPRO® immunoassay systems detect analytes using Single Molecule Counting (SMC®) technology.


Species Reactivity:
Specificity was not tested.

Cross Reactivity:
Cross-reactivity was not tested.

  • Minimum of 5 serum samples spiked with average recovery of 97% with a range of 70-138%
  • Minimum of 5 plasma samples spiked with average recovery of 97% with a range of 81-127%
  • Minimum of 5 CSF samples spiked with average recovery of 108% with a range of 82-146%


The sensitivity of the Single Molecule Counting (SMC®) technology gives the SMC® Human Phospho-Tau (T181) High Sensitivity Immunoassay Kit unparalleled performance in the quantification of Phospho-Tau (T181) in human serum, plasma, and CSF.

This new streamline kit has the following features including:
  • Improved options for sample prep and incubation
  • Lyophilization of the standard provides the kit at one storage condition
  • Removal of a plate transfer step
  • Increased reagent volumes to accommodate automation
  • Validated to run on both SMCxPRO® and Erenna

Research Category:
  • Neuroscience
  • Neurological

Research Sub-Category:
  • Alzheimer′s Disease
  • Aging
  • Nervous System
  • Neurodegenerative Diseases
  • Neurofilament & Neuron Metabolism
  • Neuronal & Glial Markers
  • Neuroregenerative Medicine
  • Neuroscience


96 well assay


  • Assay Buffer
  • pTau T181 Coated Beads
  • Standard Diluent
  • pTau T181 Detection Antibody
  • pTau T181 Standard
  • 10X Wash Buffer
  • Buffer D
  • Elution Buffer B

Legal Information

SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


Skull and crossbonesHealth hazard



Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation


Respiratory Tract

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).


Product Number
Pack Size/Quantity

Additional examples:





enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service