04-1583
Anti-Interleukin 21 (IL-21) Antibody, clone 1G8
clone AB43.50.32H5.1G8, from mouse
Synonym(s):
interleukin 2, interleukin-2, interleukin-21 isoform
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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General description
Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin′s lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin′s lymphoma including clusters of other immune cells gathered around HL cells in cultures.
Immunogen
Full length recombinant protein corresponding to human IL-21.
Application
ELISA Analysis: A previous lot was used by an independent laboratory in ELISA. (Dr. Gerard Zurawski, Baylor Institute for Immunology Research, Dallas, TX)
This Anti-Interleukin 21 (IL-21) Antibody, clone 1G8 is validated for use in WB, ELISA for the detection of Interleukin 21 (IL-21).
Quality
Evaluated by Western Blot from human IL-21 recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-21 on 10 µg of human IL-21 recombinant protein.
Target description
Two isoforms are observed at ~16 and ~18 kDa
Physical form
Format: Purified
Analysis Note
Control
Human IL-21 recombinant protein
Human IL-21 recombinant protein
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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