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1.00886

SAFC

Ethyl 4-hydroxybenzoate sodium salt

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

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Synonym(s):
Ethyl 4-hydroxybenzoate sodium salt, p-Hydroxybenzoic acid ethyl ester sodium salt, Ethylparaben sodium salt
Empirical Formula (Hill Notation):
C9H9NaO3
CAS Number:
35285-68-8
Molecular Weight:
188.16
EC Index Number:
252-487-6

Agency

BP
NF
Ph. Eur.

Quality Level

500

product line

EMPROVE® ESSENTIAL

form

solid

pH

10 (20 °C, 1 g/L in H2O)

bp

297 °C/1013 hPa (free ester,decomposition)

mp

>115 °C (free ester)

transition temp

flash point 121 °C

solubility

1000 g/L

application(s)

liquid formulation
ophthalmics
pharmaceutical

storage temp.

15-25°C

InChI

1S/C9H10O3.Na/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6,10H,2H2,1H3;/q;+1/p-1

InChI key

QYNMSPKSYXPZHG-UHFFFAOYSA-M

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1 of 4

This Item
1.067561.074288.17034
Ethyl 4-hydroxybenzoate sodium salt EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

SAFC

1.00886

Ethyl 4-hydroxybenzoate sodium salt

Methyl 4-hydroxybenzoate sodium salt EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

SAFC

1.06756

Methyl 4-hydroxybenzoate sodium salt

Propyl 4-hydroxybenzoate sodium salt EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

SAFC

1.07428

Propyl 4-hydroxybenzoate sodium salt

Sodium dodecyl sulfate EMPROVE® ESSENTIAL, Ph. Eur.

SAFC

8.17034

Sodium dodecyl sulfate

product line

EMPROVE® ESSENTIAL

product line

EMPROVE® ESSENTIAL

product line

EMPROVE® ESSENTIAL

product line

EMPROVE® ESSENTIAL

form

solid

form

solid

form

solid

form

solid

pH

10 (20 °C, 1 g/L in H2O)

pH

9.7-10.3 (1 g/L in H2O)

pH

9.5-10.5 (20 °C, 1 g/L in H2O)

pH

6-9 (20 °C, 10 g/L in H2O)

bp

297 °C/1013 hPa (free ester,decomposition)

bp

-

bp

-

bp

-

mp

>115 °C (free ester)

mp

>125 °C

mp

302 °C

mp

204-207 °C

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Ethyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard ethyl 4-hydroxybenzoate.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

249.8 °F

Flash Point(C)

121 °C

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