MilliporeSigma
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1.03725

Supelco

Acetonitrile

for UHPLC-MS LiChrosolv®

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Synonym(s):
ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein:
741857
MDL number:
EC Index Number:
200-835-2

vapor density

1.41 (vs air)

Quality Level

vapor pressure

72.8 mmHg ( 20 °C)
97 hPa ( 20 °C)

product line

LiChrosolv®

Assay

≥99.9% (GC)

form

liquid

autoignition temp.

524 °C
973 °F

expl. lim.

16 %

technique(s)

UHPLC: suitable

refractive index

n20/D 1.344 (lit.)

bp

81-82 °C (lit.)

mp

−45 °C (lit.)

transition temp

flash point 2 °C

density

0.786 g/mL at 25 °C (lit.)

format

neat

storage temp.

2-30°C

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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1 of 4

This Item
1.142911.00029271004
Acetonitrile for UHPLC-MS LiChrosolv®

Supelco

1.03725

Acetonitrile

Acetonitrile isocratic grade for liquid chromatography LiChrosolv®

Supelco

1.14291

Acetonitrile

Acetonitrile hypergrade for LC-MS LiChrosolv®

Supelco

1.00029

Acetonitrile

Acetonitrile anhydrous, 99.8%

Sigma-Aldrich

271004

Acetonitrile

vapor pressure

72.8 mmHg ( 20 °C), 97 hPa ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C), 97 hPa ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C), 97 hPa ( 20 °C)

vapor pressure

72.8 mmHg ( 20 °C)

assay

≥99.9% (GC)

assay

≥99.8% (GC)

assay

≥99.9% (GC)

assay

99.8%

form

liquid

form

liquid

form

liquid

form

liquid

autoignition temp.

524 °C, 973 °F

autoignition temp.

524 °C, 973 °F

autoignition temp.

524 °C, 973 °F

autoignition temp.

973 °F

expl. lim.

16 %

expl. lim.

16 %

expl. lim.

16 %

expl. lim.

16 %

General description

LiChrosolv® solvents show high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level. This makes them suitable for reproducible separations.
Acetonitrile is a polar aprotic solvent, which is used as an intermediate in organic synthesis. It has a low viscosity, high elution strength and miscibility in water that make it viable in many chromatography systems. It can also be utilized in spectrophotometric and fluorimetric technques.

Application

Intended for U/HPLC and LC-MS/MS applications.

Featured as a solvent in screening of benzofurans and ethylphenidate psychostimulants in serum, urine, and hair samples by UHPLC-MS/MS.
The product is an organic solvent, used as a mobile phase/extraction solvent in the ultra-high performance liquid chromatorgraphy - tandem mass spectrometry (UHPLC-MS/MS) analysis of pesticides in tobacco samples.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup


Certificates of Analysis (COA)

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Intoxication caused by new psychostimulants: analytical methods to disclose acute and chronic use of benzofurans and ethylphenidate
Barcelo B, et al.
International Journal of Legal Medicine, 131(6), 1543-1553 (2017)
Acetonitrile, the polarity chameleon.
P K Zarzycki et al.
Analytical and bioanalytical chemistry, 397(3), 905-908 (2010-04-13)
Roberto Nisticò et al.
Nanomaterials (Basel, Switzerland), 9(8) (2019-08-02)
The photodegradation of an aqueous solution of diclofenac (DCF) has been attempted in the presence of hydrogen peroxide and organic/inorganic hybrid magnetic materials under simulated and real solar light. The hybrid magnetic materials have been prepared via coprecipitation synthesis starting
Gabrieli Bernardi et al.
Talanta, 161, 40-47 (2016-10-23)
An effective method has been developed and validated for the determination of residues of 55 pesticides in tobacco. The proposed sample preparation method is based on acetonitrile extraction, low-temperature precipitation (LTP) and dispersive solid phase extraction (d-SPE) clean-up. Gas chromatography
Duygu Eryavuz Onmaz et al.
Clinica chimica acta; international journal of clinical chemistry, 497, 120-124 (2019-07-28)
Imatinib has favorable pharmacokinetic properties, but primary and secondary resistance mechanisms may cause a decrease in clinical response over time. There is a positive correlation between serum imatinib concentrations and treatment response. Our aim was to develop a method for

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