MilliporeSigma
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1.08432

SAFC

Urea

crystalline, EMPROVE® API, Ph. Eur., BP, USP

Synonym(s):
Carbamide, Carbonyl diamide, Carbonyldiamine, Diaminomethanone, Carbonyldiamide
Linear Formula:
NH2CONH2
CAS Number:
Molecular Weight:
60.06
Beilstein:
635724
MDL number:
EC Index Number:
200-315-5

biological source

synthetic

Quality Level

grade

GMO free
GMP
Halal
Kosher

Agency

BP
Ph. Eur.
USP

product line

EMPROVE® API

form

crystalline

impurities

low in endotoxins

mp

132-135 °C (lit.)

density

1.335 g/mL at 25 °C (lit.)

application(s)

ophthalmics
pharmaceutical
semi-solid formulation

foreign activity

Aflatoxin free

storage temp.

2-25°C

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

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1 of 4

This Item
1706698U125066612-M
Urea crystalline, EMPROVE® API, Ph. Eur., BP, USP

SAFC

1.08432

Urea

Urea United States Pharmacopeia (USP) Reference Standard

USP

1706698

Urea

Urea ReagentPlus®, ≥99.5%, pellets

Sigma-Aldrich

U1250

Urea

Urea End product of the urea cycle. A topical keratolytic agent.

Millipore

66612-M

Urea

biological source

synthetic

biological source

-

biological source

-

biological source

-

grade

GMO free

grade

pharmaceutical primary standard

grade

-

grade

-

agency

BP

agency

-

agency

-

agency

-

product line

EMPROVE® API

product line

-

product line

ReagentPlus®

product line

-

form

crystalline

form

-

form

pellets

form

solid

impurities

low in endotoxins

impurities

-

impurities

-

impurities

≤0.01% insoluble material

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Urea as an active pharmaceutical ingedient is used mainly in dermatology for cremes and ointments and for ophthalmic applications. Urea crystalline Emprove® API is manufactured under ICH Q7. A CEP and an US-DMF is available.
Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Packaging

1.08432.0001 // 3x 1kg // PE bottle
1.08432.1000 // 1kg // PE bottle
1.08432.5000 // 5kg // PE bottle
1.08432.9029 // 25 kg //Double PE bag

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Please enter the Product Number and Lot Number.

Certificate of Quality

Please enter the Product Number and Lot Number.

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials.

Elemental Impurities Information

Available by subscription or for a fee

API Information Package

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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