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Folin-Ciocalteu′s phenol reagent

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Reagent for phenol and bovine serum albumine acc. to Folin and Ciocalteu




<0.5 (20 °C in H2O)


1.24 g/cm3 at 20 °C

storage temp.



  • Phytochemicals, Antioxidant and Antimicrobial Potentials and LC-MS Analysis of Centaurea parviflora Desf. Extracts: This research utilizes Folin-Ciocalteu reagent to analyze the antioxidant properties in Centaurea parviflora, emphasizing its application in identifying potent natural antioxidants which is crucial in pharmaceutical, nutraceutical, and cosmetic industries (Hechaichi et al., 2023).

  • Optimization of microwave-assisted extraction of antioxidant compounds from spring onion leaves using Box-Behnken design: This study showcases the use of Folin-Ciocalteu reagent to determine the efficiency of microwave-assisted extraction methods in isolating antioxidants, pivotal for enhancing food safety and shelf life (Aquino et al., 2023).

  • Effect of malting on phenolic compounds and radical scavenging activity in grains and breakfast cereals: Folin-Ciocalteu reagent is employed here to measure total phenolic content, providing insights into how malting influences the antioxidant properties of grains, essential for food scientists and health-focused food industries (Vingrys et al., 2022).

  • Advancing quantification methods for polyphenols in brown seaweeds-applying a selective qNMR method compared with the TPC assay: This research explores the comparative effectiveness of Folin-Ciocalteu reagent against advanced qNMR methods for quantifying polyphenols, critical for accurate and efficient antioxidant analysis in marine bioproducts (Wekre et al., 2022).

  • An Endemic Plant of the Mediterranean Area: Phytochemical Characterization of Strawberry Tree (Arbutus unedo L.) Fruits Extracts at Different Ripening Stages: Utilizing Folin-Ciocalteu reagent, this study evaluates the phenolic content and antioxidant capacity of strawberry tree fruits at various stages, highlighting its importance in developing functional foods and nutraceuticals (Scarano et al., 2022).

Analysis Note

Equivalent acid: c(H⁺) = 2 mol/l (2N)
Sensitivity (to phenol): conforms
Sensitivity (to bovine serum albumin): conforms





Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1

Storage Class

8B - Non-combustible, corrosive hazardous materials




Not applicable


Not applicable

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