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110175-M

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Acetyl-Pepstatin

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).

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Synonym(s):
Acetyl-Pepstatin, Ac-Val-Val-(3S,4S)-Sta-Ala-(3S,4S)-Sta-OH
Empirical Formula (Hill Notation):
C31H57N5O9
CAS Number:
Molecular Weight:
643.81

Quality Level

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

50% acetic acid: 5 mg/mL

storage temp.

−20°C

InChI

1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1

InChI key

WKYBEGDEGRCZNF-LBTYKNIQSA-N

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This Item
PEPS-RO516481-MP2032
Acetyl-Pepstatin An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).

Millipore

110175-M

Acetyl-Pepstatin

Pepstatin from Streptomyces species

Roche

PEPS-RO

Pepstatin

Sigma-Aldrich

Sigma-Aldrich

P2032

Pepstatin A−Agarose

form

solid

form

lyophilized

form

solid

form

saline suspension

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Roche

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze

storage condition

-

storage condition

OK to freeze

storage condition

-

color

white

color

-

color

white

color

-

solubility

50% acetic acid: 5 mg/mL

solubility

ethanol: 1 mg/mL, methanol: 1 mg/mL, acetic acid: soluble 300 μg/mL (6N), pyridine: soluble, water: insoluble

solubility

DMSO: 1 mg/mL, methanol: 1 mg/mL

solubility

-

General description

An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7).
An aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (Ki = 20 nM at pH 4.7) and HIV-2 proteinase (Ki = 5 nM at pH 4.7). Acts as a substrate-analog inhibitor.

Biochem/physiol Actions

Primary Target
HIV-1 proteinase
Target Ki: 20 nM at pH 4.7 against HIV-1 proteinase

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Ulrich, B., et al. 2000. Protein Sci.9, 2232.
Song, K., et al. 1992. Kidney Int.42, 639.
Richards, A.D., et al. 1989. FEBS Lett. 247, 113.
Richards, A.D., et al. 1989. FEBS Lett. 253, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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