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124036-M

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Akt Inhibitor XVIII, SC66

The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonym(s):
Akt Inhibitor XVIII, SC66, (2 E,6 E)-2,6- bis(4-Pyridylmethylene)cyclohexanone, (2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone
Empirical Formula (Hill Notation):
C18H16N2O
Molecular Weight:
276.33

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 25 mg/mL

storage temp.

2-8°C

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This Item
5.05477124005567731
Akt Inhibitor XVIII, SC66 The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

124036-M

Akt Inhibitor XVIII, SC66

Sigma-Aldrich

5.05477

NAE Inhibitor, MLN4924

Akt Inhibitor The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

124005

Akt Inhibitor

Sphingosine Kinase Inhibitor The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

567731

Sphingosine Kinase Inhibitor

form

solid

form

solid

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 25 mg/mL

solubility

DMSO: 100 mg/mL

solubility

DMSO: 200 mg/mL

solubility

DMSO: 5 mg/mL

General description

A cell-permeable pyridine compound that represses Akt activation by allosterically disrupting Akt-PH domain binding to PIP3 and directly facilitating Akt ubiquitination with little proteasomal or deubiquitination activity. Blocks phosphorylations of Akt-Ser473 and downstream targets TSC, FOXO and PRAS40 in HEK293T cells at 8 µg/ml with minimal effect on pAkt-Thr450. Shown to be highly efficacious towards PI 3-K inhibitor resistant Akt1-E17K mutant and exert synergistic apoptotic activity with LY 294002 (Cat. No. 440202) against HeLa cells. Suppresses tumor growth in a mouse HEK293T-xenograft model (30 mg/kg, s.c., twice per week).
A cell-permeable pyridine compound that selectively targets Akt, but not PLCδ, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 (Cat. Nos. 124017 & 124018) competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4 M) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30 mg/kg), Synergizes with LY294002 (Cat. Nos. 440202 & 440204) in cell death induction in HeLa and HS-Sultan cultures in vitro.

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Jo, H., et al. 2011. Proc. Natl. Acad. Sci. USA108, 6486.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2


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