1.52025

Chromolith^® HighResolution RP-18 endcapped (monolithic) HPLC Columns

L × I.D. 5 mm x 4.6 mm Guard Cartridges (3 pieces)

• Synonym(s): Chromolith^® HighResolution RP-18 endcapped 5-4.6 guard cartridges (3 pieces)
• UNSPSC Code: 41115709
• NACRES: SB.52

Properties

• product name: Chromolith^® HighResolution RP-18 endcapped, L × I.D. 5 mm x 4.6 mm guard cartridges (3 pieces)
• material: PEEK column
• Quality Level: 100
• agency: suitable for ISO/CEN 6304.09; suitable for USP L1
• product line: Chromolith^®
• feature: endcapped; endcapped
• packaging: pkg of 3 ea
• extent of labeling: 15% Carbon loading; 18% Carbon loading
• parameter: 200 bar pressure; 400 bar pressure; 45 °C max. temp.; 50 °C max. temp.
• technique(s): HPLC: suitable; HPLC: suitable; LC/MS: suitable; mass spectrometry (MS): suitable (High); mass spectrometry (MS): suitable (High)
• column L × I.D.: 0.5 cm × 4.6 mm
• surface area: 250 m²/g × 250 m²/g
• matrix: highly porous; monolithic silica; monolithic silica
• matrix active group: C18 bonding phase, octadecylsilane (ODS); C18 bonding phase
• pore size: 1.15 μm macroporosity; 1.5 μm macroporosity; 15 nm mesoporosity; 15 nm mesoporosity
• operating pH range: 2-7.5; 2-7.5
• separation technique: reversed phase
• storage temp.: no temp limit

Description

General description

Although the Chromolith^® columns are well known for their robustness and longevity, guard columns are available to prolong the lifespan of Chromolith^® analytical columns even further. These guard cartridges require a special holder.

Chromolith^® HighResolution RP-18 endcapped 5-4.6 guard cartridges are extremely easy to use. The guard cartridges are simply added directly in front of the main column to protect it from chemical or mechanical contamination. Due to the benefits of monolithic technology, and the convenience of Chromolith^® guard columns, they are also popular for use with classical particulate columns. Moreover, guard columns can be used as trap columns when large sample volumes are to be injected. Guard columns should be changed frequently in order to avoid excessive accumulation of impurities.

Chromolith^® columns are made of monolithic silica with a characteristic bimodal pore structure.

Chromolith^® HighResolution RP-18 endcapped 5-4.6 guard cartridges are used with the Chromolith^® Guard Cartridge Holder 5 mm x 4.6 mm [1.52032]

Learn more:
Brochure: Race through your Separations on Any System. Chromolith^® Monolithic Silica HPLC Columns

All Supelco HPLC Columns, including monolithic Chromolith^® columns, are fully compatible to all HPLC and UHPLC Instruments.
Supelco HPLC Products: The Best Choice for Any LC Instrument

Application

• A Novel and Sensitive LC-MS/MS Method for the Quantitation of Ceftiofur in Pharmaceutical Preparations and Milk Samples.: This study, conducted by Levent S, Özcan S, Geven A, and Can NÖ, presents a new LC-MS/MS method utilizing Chromolith^® HighResolution RP-18 endcapped columns. The method provides high sensitivity and specificity for the quantitation of ceftiofur, a veterinary antibiotic, in both pharmaceutical preparations and milk samples, demonstrating its potential for robust analytical applications in pharmaceutical and food safety contexts (Levent et al., 2021).

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids