208724

Calpain Inhibitor IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Calpain Inhibitor IV, Z-LLY-FMK
• Empirical Formula (Hill Notation): C₃₀H₄₀FN₃O₆
• Molecular Weight: 557.65
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white to pale yellow
• solubility: DMSO: 25 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Leu-Leu-Tyr-CH₂F

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable