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219379

Sigma-Aldrich

Cathepsin K Inhibitor II

The Cathepsin K Inhibitor II controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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Synonym(s):
Cathepsin K Inhibitor II, Inhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
Empirical Formula (Hill Notation):
C35H51N7O8
Molecular Weight:
697.82

Quality Level

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 1 mg/mL

shipped in

wet ice

storage temp.

−20°C

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Cathepsin K Inhibitor II

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Cathepsin K Inhibitor I

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Cathepsin K Inhibitor III

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219433

Cathepsin L Inhibitor IV

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

lyophilized solid

form

lyophilized solid

form

lyophilized solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 1 mg/mL

solubility

methanol: 1 mg/mL, DMSO: soluble

solubility

DMSO: 1 mg/mL

solubility

DMSO: 5 mg/mL

General description

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cathepsin K
Product does not compete with ATP.
Reversible: yes
Target Ki: 6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Wang, D., et al. 2002. Biochemistry41, 8849.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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