252805

DHEA

≥97% (HPLC), powder, GABAA receptor negative modulator, Calbiochem^®

• Synonym(s): DHEA, Dehydro- epi-androsterone, Dehydroisoandrosterone, Prasterone, 3-Hydroxyandrost-5-en-17-one
• Empirical Formula (Hill Notation): C₁₉H₂₈O₂
• CAS Number: 53-43-0
• Molecular Weight: 288.42
• MDL number: MFCD00003613
• UNSPSC Code: 12352211
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: ethanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
• InChI key: FMGSKLZLMKYGDP-USOAJAOKSA-N

Description

General description

Major secretory steroidal product of the adrenal gland. DHEA and its sulfated metabolite, DHEA-S, are negative modulators of GABA_A receptors.

Major secretory steroidal product of the adrenal gland. DHEA, and its sulfated metobolite DHEA-S, are negative modulators of GABA_A receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Negative modulators of GABAA receptors

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Other Notes

Hansen, S.L., et al. 1999. Mol. Pharmacol. 55, 489.
Imamura, M., and Prasad, C. 1998. Biochem. Biophys. Res. Commun.243, 771.
Majewska, M.D., et al. 1990. Brain Res.526, 143.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08
• signalword: Warning
• hcodes: H361fd
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable