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347436

Sigma-Aldrich

GGACK

An irreversible inhibitor of urokinase (IC₅₀ 1 µM) and Factor Xa.

Synonym(s):

GGACK, Glu-Gly-Arg-chloromethyl Ketone

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About This Item

Empirical Formula (Hill Notation):
C14H25ClN6O5
Molecular Weight:
392.84
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

assay

≥80% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 50 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An irreversible inhibitor of urokinase (IC50<1 µM) and Factor Xa.

Biochem/physiol Actions

Cell permeable: no
Primary Target
urokinase
Product does not compete with ATP.
Reversible: no
Target IC50: <1 µM against urokinase

Warning

Toxicity: Standard Handling (A)

Sequence

H-Glu-Gly-Arg-CMK

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Avoid freeze/thaw cycles of stock solution.

Other Notes

Kettner, C., and Shaw, E. 1979. Biochim. Biophys. Acta569, 31.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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