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Sigma-Aldrich

PKG Inhibitor

The PKG Inhibitor controls the biological activity of PKG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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Synonym(s):
PKG Inhibitor, Protein Kinase G Inhibitor, RKRARKE
Empirical Formula (Hill Notation):
C38H74N18O10
Molecular Weight:
943.11

Quality Level

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A more specific, reversible, and substrate competitive inhibitor of protein kinase G (Ki = 86 µM) relative to protein kinase A (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser32 to Ala32) of histone H2B (amino acids 29-35).
A specific, reversible, and substrate competitive inhibitor of PKG (Ki = 86 µM) relative to PKA (Ki = 550 µM). Sequence corresponds to a non-phosphorylatable analog (Ser32 to Ala32) of histone H2B (amino acids 29-35).

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: yes
Target Ki: 86 µM against protein kinase G

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Lys-Arg-Ala-Arg-Lys-Glu-OH

Other Notes

Glass, D.B., et al. 1983. Biochem. J.213, 159.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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