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D-myo-Inositol 1,2,3,4,5,6-Hexakisphosphate, Dodecasodium Salt, Zea mays

Major phosphorus compound in plants that chelates with a variety of di- and trivalent cations.

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Synonym(s):
D-myo-Inositol 1,2,3,4,5,6-Hexakisphosphate, Dodecasodium Salt, Zea mays, D-Ins(1,2,3,4,5,6)P₆, 12Na, Phytic Acid, 12Na
Empirical Formula (Hill Notation):
C6H6O24P6 · 12Na
CAS Number:
Molecular Weight:
923.82

Quality Level

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white to off-white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C6H18O24P6.12Na/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15;;;;;;;;;;;;/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24);;;;;;;;;;;;/q;12*+1/p-12

InChI key

KETSPIPODMGOEJ-UHFFFAOYSA-B

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This Item
57570407137487870
vibrant-m

57570

myo-Inositol

vibrant-m

487870

p-Nitrophenyl-β-D-xylopyranoside

assay

≥85% (HPLC)

assay

≥99.0% (HPLC)

assay

≥95% (TLC)

assay

≥98% (TLC)

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

color

white to off-white

color

-

color

white

color

-

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

ambient

General description

Major phosphorus compound in plants that chelates with a variety of di- and trivalent cations. Reported to suppress damaging iron-catalyzed redox reactions.
Major phosphorus compound in plants. Chelates with a variety of di- and trivalent cations. Inhibits growth and induces differentiation of PC-3 human prostate cancer cells. Also reported to suppress damaging iron-catalyzed redox reactions.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Chelates with a variety of di- and trivalent cations
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shamsuddin, A.M., and Yang, G.Y. 1995. Carcinogenesis 16, 1975.
Graf, E., and Eaton, J.W. 1993. Nutr. Cancer19, 11.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Hayley Whitfield et al.
The Biochemical journal, 477(14), 2621-2638 (2020-07-25)
Inositol polyphosphates are ubiquitous molecular signals in metazoans, as are their pyrophosphorylated derivatives that bear a so-called 'high-energy' phosphoanhydride bond. A structural rationale is provided for the ability of Arabidopsis inositol tris/tetrakisphosphate kinase 1 to discriminate between symmetric and enantiomeric
Yann Desfougères et al.
Methods in molecular biology (Clifton, N.J.), 2091, 59-71 (2019-11-28)
The yeast Saccharomyces cerevisiae has given us much information on the metabolism and function of inositol polyphosphates and inorganic polyphosphate. To expand our knowledge of the metabolic as well as functional connections between inositol polyphosphates and inorganic polyphosphate, we have
Jone Paesmans et al.
eLife, 9 (2020-12-23)
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer's disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 are associated with

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