5.05762

(+/-)-Clopidogrel Hydrogensulfate

• Synonym(s): (+/-)-Clopidogrel Hydrogensulfate, Purinergic P2Y12 Receptor Antagonist, (+/-)-Clopidogrel, Plavix
• Empirical Formula (Hill Notation): C₁₆H₁₆ClNO₂S · xH₂SO₄
• CAS Number: 135046-48-9
• Molecular Weight: 321.82 (free base basis)
• MDL number: MFCD05865229
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 25 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)
• InChI key: FDEODCTUSIWGLK-UHFFFAOYSA-N

Description

General description

A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y₁₂ receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.

Biochem/physiol Actions

Primary Target
P2Y₁₂

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Liu, O., et al. 2012. PLoS One.7, e51707.

Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H314 - H411
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible, corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable