5.05881

(R)-(+)-SKF38393 Hydrochloride

• Synonym(s): (R)-(+)-SKF38393 Hydrochloride, Dopamine D₁/D₅ Receptor Partial Agonist, (R)-SKF-38393 Hydrochloride, SKF-38393, SKF38393, SKF 38393
• Empirical Formula (Hill Notation): C₁₆H₁₇NO₂ · xHCl
• CAS Number: 81702-42-3
• Molecular Weight: 255.31 (free base basis)
• MDL number: MFCD00055189
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 100 mM
• storage temp.: −20°C
• InChI: 1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• InChI key: YEWHJCLOUYPAOH-PFEQFJNWSA-N

Description

General description

A benzazepine derivative that acts as a selective Dopamine D₁/D₅ receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

A benzazepine derivative that acts as a selective Dopamine D₁/D₅ receptor partial agonist. Examination of the isomers in several in vitro and in vivo tests for both central and peripheral dopaminergic activity revealed that activity resided almost exclusively in the R isomer. The results suggest that the properly oriented 1-phenyl substituent of 1 is important for dopamine-like activity. Reported to have stimulant and anorectic effects.

Biochem/physiol Actions

Primary Target
D₁

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Trampus, M. et al. 1993. J. Pharmacol.235, 83.
Cooper, S. J. et al. 1990. Psychopharmacol.100, 182.
Dubois, A. et al. 1986. Neurosci.19, 125.
Kaiser, C. C. et al. 1982. J. Med. Chem.25, 697.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable