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681668

Sigma-Aldrich

Wnt Synergist, QS11

A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).

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Synonym(s):
Wnt Synergist, QS11, QS11, Wnt Pathway Activator II, Wnt Pathway Activator II, QS11
Empirical Formula (Hill Notation):
C36H33N5O2
CAS Number:
Molecular Weight:
567.68

Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale amber

solubility

ethanol: 20 mg/mL
DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C36H33N5O2/c42-23-31(20-25-8-3-1-4-9-25)38-34-33-35(40-36(39-34)43-32-19-18-28-12-7-13-30(28)21-32)41(24-37-33)22-26-14-16-29(17-15-26)27-10-5-2-6-11-27/h1-6,8-11,14-19,21,24,31,42H,7,12-13,20,22-23H2,(H,38,39,40)/t31-/m0/s1

InChI key

DOKZLKDGUQWMSX-HKBQPEDESA-N

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Wnt Synergist, QS11

vibrant-m

681665

Wnt Agonist

vibrant-m

412400

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vibrant-m

681667

Wnt Agonist II, SKL2001

form

solid

form

solid (sticky)

form

solid

form

solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

ethanol: 20 mg/mL, DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: 100 mg/mL, clear, red

General description

A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA104, 7444.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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