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8.55104

Sigma-Aldrich

2-(4-Bromomethylphenoxy)ethyl polystyrene HL

Novabiochem®

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About This Item

UNSPSC Code:
13111023
NACRES:
NA.22

$1,050.00

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Request a Bulk Order

Quality Level

200

product line

Novabiochem®

form

beads

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

storage temp.

2-8°C

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This Item
1.077311.077391.07736
Silica gel 60 PF₂₅₄ for preparative thin layer chromatography

1.07747

Silica gel 60 PF₂₅₄

Silica gel 60 G for thin-layer chromatography

1.07731

Silica gel 60 G

Silica gel 60 HF₂₅₄ for thin-layer chromatography

1.07739

Silica gel 60 HF₂₅₄

Silica gel 60 H for thin-layer chromatography

1.07736

Silica gel 60 H

particle size

5-40 μm

particle size

5-40 μm

particle size

5-40 μm

particle size

5-40 μm

pore size

60 Å medium pore diameter

pore size

60 Å medium pore diameter

pore size

60 Å medium pore diameter

pore size

60 Å medium pore diameter

pH

7 (20 °C, 100 g/L in H2O, slurry)

pH

7 (20 °C, 100 g/L in H2O, slurry)

pH

7 (20 °C, 100 g/L in H2O, slurry)

pH

7 (20 °C, 100 g/L in H2O, slurry)

packaging

pkg of 2.5 kg

packaging

pkg of 25 kg

packaging

pkg of 2.5 kg

packaging

pkg of 25 kg

bp

2230 °C

bp

2230 °C

bp

2230 °C

bp

2230 °C

General description

This versatile support is an excellent tool for the solid phase immobilization of carboxylic acids, amines and alcohols. Acids are attached by treating the resin with the appropriate DIPEA salt in DMF in the presence of CsI [1,2]. Reaction with aryl and alkyl amines provides resin-bound secondary amines. These can be readily acylated to give sulfonamides or anilides that can be cleaved with 95% TFA. Since this resin does not contain a benzylic ether linkage, it gives cleaner products than similar supports derived from Wang resin, free from impurities arising from breakdown of the linker. For examples using a similar resin, please see [1,2,3,4].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

[1] J. W. Corbett, et al. (1997) Bioorg. Med. Chem. Lett., 7,1371.
[2] G. A. Morales, et al. (1998) J. Org. Chem., 63,1172.
[3] K. Ngu & D. V. Patel (1997) Tetrahedron Lett., 38, 973.
[4] B. Raju & T. P. Kogan (1997) Tetrahedron Lett., 38, 4965.

Linkage

Replaces: 01-64-0400

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Swelling Volume (in DMF): lot specific result
Loading (determined by elemntal analysis of bromine): 0.80 - 1.30 mmol/g
The polymer matrix is copoly (styrene - 1 % DVB), 100 - 200 mesh

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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