ABN442

Anti-FGF-20 Antibody

from rabbit, purified by affinity chromatography

• Synonym(s): Fibroblast growth factor 20, FGF-20
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human
• species reactivity (predicted by homology): guinea pig (based on 100% sequence homology), ferret (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• technique(s): immunohistochemistry: suitable; western blot: suitable
• NCBI accession no.: NP_062825
• UniProt accession no.: Q9NP95
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... FGF20(26281)

Description

General description

FGF-20 is a recent but important neurotrophic factor that regulates multiple central nervous system developmental systems and cell functions. It is a secreted protein expressed most highly in the cerebellum but also found in other regions. FGF-20 is a pro-survival factor on neurons and specifically has been shown to protect dopaminergic neurons against a range of toxic insults in vitro, through activation of fibroblast growth factor receptor 1 (FGFR1). FGF-20 treatments also appear to protect neurons in various disease models so it is being studied as a possible therapy.

Immunogen

KLH-conjugated linear peptide corresponding to human FGF-20 near theC-terminal.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FGF-20 in human cerebral cortex, human cerebellum, and human thalamus tissue.

This Anti-FGF-20 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of FGF-20.

Quality

Evaluated by Western Blotting in transfected HEK293 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected FGF-20 in 10 µg of transfected HEK293 cell lysate.

Target description

~30 kDa observed. Uncharacterized band(s) may appear in some lysates.

Other Notes

Concentration: Please refer to lot specific datasheet.

Safety Information

• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable