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ABT280

Sigma-Aldrich

Anti-Periostin (Pan) Antibody

0.5 mg/mL, from rabbit

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Synonym(s):
Periostin, PN, Osteoblast-specific factor 2, OSF-2
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse

concentration

0.5 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Postn(50706)

General description

Periostin, also known as PN, or Osteoblast-specific factor 2 (OSF-2), and encoded by the gene POSTN/OSF2, is a secreted extracellular matrix protein that appears to be involved in inducing cell attachment and spreading as well as cell adhesion. In bone, Periostin enhances mineralization and assists in the incorporation of BMP1 protein into the fibronectin extracellular matrix of connective tissues. Periostin is preferentially expressed in periosteum and periodontal ligaments but can also be found expressed in developing heart and other tissues. Periostin is also over expressed in many cancers where is contributes to a growth-supportive role for such cancers and also aids in chemoresistance for cancers cells through the activation of the PI3K/Akt/surviving pathway.

Specificity

This antibody detects all splice variants of Periostin.

Immunogen

Linear peptide from the fasciclin 1 domain of mouse periostin.

Application

Anti-Periostin (Pan) Antibody is an antibody against Periostin (Pan) for use in western blotting & IHC.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
Western Blotting Analysis: A representative lot detected Periostin (Pan) in mouse lung extract.

Immunohistochemistry Analysis: A representative lot detected Periostin (Pan) in certain reported tissues (Kruzynska-Frejtag, A., et al. (2004). Dev Dyn. 229(4):857-868.; Butcher, J. T., et al. (2007). Dev Biol. 302(1):256-266.; Norris, R. A., et al. (2007). J Cell Biochem. 101(3):695-711.; Inai, K., et al. (2008). Dev Biol. 315(2):383-396.; Norris, R. A., et al. (2008). Dev Biol. 316(2):200-213.).

Quality

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Periostin (Pan) in 10 µg of mouse lung tissue lysate.

Target description

~75-85 kDa observed. Uniprot describes five isoforms at 93 kDa, 90 kDa, 90 kDa, 87 Kda, and 87 kDa However, this protein has been observed between 75-85 kDa

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing PBS.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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