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Key Documents

HTS007M

Sigma-Aldrich

ChemiSCREEN CCR2B Membrane Preparation

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About This Item

UNSPSC Code:
41123201
eCl@ss:
32161000
NACRES:
NA.84

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description

GPCR Class A
protein target CCR2B

Quality Level

technique(s)

radioligand binding assay (RLBA): suitable

UniProt accession no.

Gene Information

human ... CCR2(729230)

General description

FUNCTION: SwissProt: P41597 # Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
SIZE: 374 amino acids; 41915 Da
SUBUNIT: Binds to HIV-1 Tat.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
PTM: N-glycosylated.
SIMILARITY: SwissProt: P41597 ## Belongs to the G-protein coupled receptor 1 family.

Physical form

Liquid in packaging buffer: 50 mM Tris pH 7.4, 10% glycerol and 1% BSA with no preservatives.
Packaging method: Membrane protein was adjusted to 1 mg/ml in 1 ml packaging buffer, rapidly frozen, and stored at -80°C.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Certificates of Analysis (COA)

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