MAB10762

Anti-Transthyretin Antibody, clone 7G8-E11-E7

clone 7G8-E11-E7, from mouse

• Synonym(s): prealbumin, amyloidosis type I, thyroxine-binding prealbumin, TBPA, TTR, ATTR
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 7G8-E11-E7, monoclonal
• species reactivity: human
• technique(s): ELISA: suitable; western blot: suitable
• isotype: IgG2aκ
• NCBI accession no.: NP_000362.1
• UniProt accession no.: P02766
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... TTR(7276)

Description

General description

Transthyretin is one of the three major thyroid hormone-binding proteins in plasma and/or cerebrospinal fluid of vertebrates. It exists mainly as a homotetrameric protein of approximately 55 kDa in plasma and, in sera and cerebrospinal fluid, is a carrier of the thyroid hormone thyroxine (T4) and retinol. While mostly known for being the transporter of thyroxine and retinol, when mutated, TTR is also well-described as the cause of familial amyloid polyneuropathy, a neurodegenerative lethal disorder characterized by systemic deposition of TTR amyloid fibrils, particularly in the peripheral nervous system. Recently, studies have shown that TTR has an important function development of peripheral and central nervous system physiology, namely by participating in behavior, in the maintenance of normal cognitive processes during ageing, amidated neuropeptide processing and nerve regeneration. Additionally, it has been proposed that TTR is neuroprotective in Alzheimer′s disease, by preventing the formation of amyloid beta fibrils (Fleming C.E. et al. (2009) Prog Neurobiol., Epub ahead of print

Specificity

This antibody recognizes Transthyretin.

Immunogen

Purified human Transthyretin.

Application

This Anti-Transthyretin Antibody, clone 7G8-E11-E7 is validated for use in ELISA, WB for the detection of Transthyretin.

Quality

Evaluated by Western Blot in human placenta lysate.

Western Blot Analysis: 2 µg/ml of this antibody detected Transthyretin in 10 µg of human placenta lysate.

Target description

Transthyretin exists mainly as a homotetrameric protein of approximately 55 kDa in plasma. A single band of ~26 kDa was observed, which is an approximate size of a dimeric component that makes up the said homotetramer.

Physical form

Format: Purified

Analysis Note

Control
Human placenta lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable