MilliporeSigma
All Photos(1)

Documents

SCC294

Sigma-Aldrich

OVSAHO Human High-grade Serous Ovarian Cancer Cell Line

Sign Into View Organizational & Contract Pricing

Synonym(s):
OVSAHO Human High-grade Serous Ovarian Cancer Cell Line

biological source

human

packaging

pkg of >1X10⁶ vials

manufacturer/tradename

Sigma-Aldrich

growth mode

N/A

technique(s)

cell culture | mammalian: suitable

shipped in

dry ice

storage temp.

≤ − 140°C

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SCC421SCC426SCC209
technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

growth mode

N/A

growth mode

N/A

growth mode

N/A

growth mode

N/A

storage temp.

≤ − 140°C

storage temp.

≤ − 140°C

storage temp.

−196°C

storage temp.

≤ − 140°C

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

manufacturer/tradename

Sigma-Aldrich

manufacturer/tradename

Millipore

manufacturer/tradename

Millipore

manufacturer/tradename

Sigma-Aldrich

General description

Ovarian cancer (OC) remains one of the leading causes of cancer-related deaths in women worldwide, with the all-stage 5-year relative survival rate across the globe of only 30 40% (Reid 2017). High-grade serous carcinoma (HGSOC) accounts for 70% of all

Application

Each vial contains ≥ 1X10⁶ viable cells.Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, Chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.Cells are negative for mycoplasma contamination.Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Ovarian cancer (OC) remains one of the leading causes of cancer-related deaths in women worldwide, with the all-stage 5-year relative survival rate across the globe of only 30–40%.1 High-grade serous carcinoma (HGSOC) accounts for 70% of all ovarian cancers and is also one of the more lethal forms of ovarian cancer due to its rapid growth and early spread to other organs in the peritoneal cavity.2 Ovarian cancer cell lines have historically been the most frequently used tumor models to prescreen experimental anticancer agents in vitro and to select specific histologic subtypes of epithelial OC for further exploration of these agents. Xenograft models relying on implantation of established EOC cell lines have also been extensively used in ovarian cancer research and are important experimental platforms for preclinical drug development.3Source OVSAHO is a permanent human ovarian carcinoma cell line established from the abdominal metastasis of a serous papillary adenocarcinoma patient.4 In addition to being a reproducible in vitro HGSOC source, OVSAHO cells have been shown to be amenable to intraperitoneal and subcutaneous4 as well as orthotopic5 heterotransplantation in nude and even immune-competent mice. OVSAHO ranked second among 47 ovarian cancer cell lines listed in the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas in having the highest genetic similarity to ovarian tumors.6 References1. Reid BM, Permuth JB, Sellers TA. 2017. Epidemiology of ovarian cancer: a review. Cancer Biol. Med. 14, 9–32.2. Lisio MA, Fu L, Goyeneche A, Gao ZH, Telleria C. 2019. High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints. Int. J. Mol. Sci. 20(4): 9523. Konstantinopoulos PA, Matulonis UA. 2013. Current Status and Evolution of Preclinical Drug Development. Models of Epithelial Ovarian Cancer. Frontiers in Oncology 3(1): 296. 4. Yanagibashi T, Gorai I, Nakazawa T, Miyagi E, Hirahara F, Kitamura H, Minaguchi H. 1997. Complexity of expression of the intermediate filaments of six new human ovarian carcinoma cell lines: new expression of cytokeratin 20. Br. J. Cancer 76: 829-835.5. Berger J, Beck TL, Mital P, Elishaev E, Sukhwani M, Oesterreich S, Vlad A, Krivak TC, Kelley III JL, Orwig K. 2015. A novel orthotopic mouse model of epithelial ovarian carcinoma demonstrating progression from early stage disease to carcinomatosis in both immune-competent and immune-deficient models Gynecologic Oncology Volume 137, Supplement 1, April 2015, Page 132 (Poster Abstract).6. Domcke S, Sinha R, Levine DA, Sander C, Schultz N. 2014. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4:2126-2126.

Features and Benefits

OVSAHO is a permanent human ovarian carcinoma cell line established from the abdominal metastasis of a serous papillary adenocarcinoma patient

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service