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00280590

Curcumin

primary reference standard

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Synonym(s):
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
Linear Formula:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS Number:
Molecular Weight:
368.38
Colour Index Number:
75300
Beilstein/REAXYS Number:
2306965
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

vapor density

13 (vs air)

form

powder or crystals

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

SMILES string

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

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This Item
085118.20354C1386
Curcumin primary reference standard

00280590

Curcumin

Curcumin analytical standard

08511

Curcumin

Curcumin for synthesis

8.20354

Curcumin

Curcumin from Curcuma longa (Turmeric), powder

C1386

Curcumin

form

powder or crystals

form

powder

form

powder

form

powder

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

manufacturer/tradename

HWI

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

vapor density

13 (vs air)

vapor density

13 (vs air)

vapor density

-

vapor density

13 (vs air)

General description

Curcumin is a bioactive component of turmeric, Curcuma longa. It has a broad spectrum of activities including antioxidant, anti-inflammatory and being anti-cancerous in nature. It has been shown to be a very powerful antioxidant, and has been found to enhance the effects of common anti-cancer drugs. It can also modulate several molecular targets such as cytokines and chemokines, a multitude of enzymes, receptors, transcription factors, cell cycle proteins and cell surface adhesion molecules.
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

It has been used as reference standard in 1H NMR and LC–MS/MS analysis for the quantification of curcumin in turmeric.
Reference Standard in the analysis of herbal medicinal products

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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Demethoxycurcumin ≥98% (HPLC)

Sigma-Aldrich

D7696

Demethoxycurcumin

Demethoxycurcumin analytical standard

Supelco

90593

Demethoxycurcumin

Bisdemethoxycurcumin ≥98% (HPLC), solid

Sigma-Aldrich

B6938

Bisdemethoxycurcumin

Bisdemethoxycurcumin analytical standard

Supelco

90594

Bisdemethoxycurcumin

Bisdemethoxycurcumin phyproof® Reference Substance

PHL89582

Bisdemethoxycurcumin

Demethoxycurcumin phyproof® Reference Substance

PHL89628

Demethoxycurcumin

USP

USP

1075305

Bisdesmethoxycurcumin

Piperine analytical standard

Supelco

75047

Piperine

B Antony et al.
Indian journal of pharmaceutical sciences, 70(4), 445-449 (2008-07-01)
Curcumin, the bioactive component of turmeric, Curcuma longa has an exceptionally wide spectrum of activities including antioxidant, anti-inflammatory and anti-cancer properties, and is currently under different phases of clinical trials for various types of soft tissue cancers. However, although in
Rapid quantitation of curcumin in turmeric via NMR and LC?tandem mass spectrometry.
Goren, Ahmet C., et al.
Food Chemistry, 113.4, 1239-1242 (2009)
Jingjing Zhu et al.
Biochimica et biophysica acta, 1833(8), 1924-1935 (2013-04-16)
Proprotein convertases (PCs) form a group of serine endoproteases that are essential for the activation of proproteins into their active form. Some PCs have been proposed to be potential therapeutic targets for cancer intervention because elevated PC activity has been
Marie-Hélène Teiten et al.
Molecular nutrition & food research, 57(9), 1619-1629 (2013-06-12)
Epigenetic alterations correspond to changes in DNA methylation, covalent modifications of histones, or altered miRNA expression patterns. These three mechanisms are interconnected and appear to be key players in tumor progression and failure of conventional chemotherapy. Dietary components emerged as
Michal Heger et al.
Pharmacological reviews, 66(1), 222-307 (2013-12-26)
This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the

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