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03738

Supelco

5-Fluorouracil

analytical standard

Synonym(s):

2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione

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About This Item

Empirical Formula (Hill Notation):
C4H3FN2O2
CAS Number:
Molecular Weight:
130.08
Beilstein/REAXYS Number:
127172
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

mp

282-286 °C (dec.) (lit.)

application(s)

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

SMILES string

FC1=CNC(=O)NC1=O

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1 of 4

This Item
100069910005651134007
grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

indocyanine green

API family

acebutolol

API family

acamprosate

API family

-

General description

5-Fluorouracil is an anti-tumor agent, widely used in the treatment of various malignancies.[1][2]

Application

5-Fluorouracil may be used as an analytical standard for the determination of the analyte in hospital effluents by capillary electrophoresis,[3] and in biological samples[4][5] and environmental samples[6] by chromatography based techniques.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3


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    G Micoli et al.
    Journal of chromatography. B, Biomedical sciences and applications, 750(1), 25-32 (2001-02-24)
    5-Fluorouracil (5-FU) is one of the most widely used antineoplastic drugs. It can be therefore considered to be a model compound for the identification of exposure routes during preparation and administration of cytostatic agents, especially for nucleoside analogue drugs. In
    5-fluorouracil: mechanisms of action and clinical strategies
    Longley DB, et al.
    Nature Reviews. Cancer, 3(5), 330-338 (2003)
    A sensitive method for determination of 5-fluorouracil and 5-fluoro-2'-deoxyuridine in human plasma by high-pressure liquid chromatography.
    A R Buckpitt et al.
    Analytical biochemistry, 106(2), 432-437 (1980-08-01)
    Susanne N Mahnik et al.
    Analytical and bioanalytical chemistry, 380(1), 31-35 (2004-09-15)
    Cytostatic anticancer drugs are an increasingly important issue in the environmental debate, mainly due to the lack of knowledge about the fate of these toxic substances. Over the last decades, 5-fluorouracil (5-FU) has been one of the most frequently used
    Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
    Carethers JM, et al.
    Gastroenterology, 126(2), 394-401 (2004)

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