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03970590

Epigallocatechin gallate

primary reference standard

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Synonym(s):
(−)-Epigallocatechin gallate, (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate, EGCG
Empirical Formula (Hill Notation):
C22H18O11
CAS Number:
Molecular Weight:
458.37
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

application(s)

food and beverages

storage temp.

−20°C

SMILES string

Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4

InChI

1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

InChI key

WMBWREPUVVBILR-WIYYLYMNSA-N

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This Item
PHR1333PHL89656Y0001936
Epigallocatechin gallate primary reference standard

03970590

Epigallocatechin gallate

Epigallocatechin gallate Pharmaceutical Secondary Standard; Certified Reference Material

PHR1333

Epigallocatechin gallate

(−)-Epigallocatechin 3-gallate phyproof® Reference Substance

PHL89656

(−)-Epigallocatechin 3-gallate

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

manufacturer/tradename

HWI

manufacturer/tradename

-

manufacturer/tradename

PhytoLab

manufacturer/tradename

EDQM

application(s)

food and beverages

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Reference Standard in the analysis of herbal medicinal products

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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(−)-Epigallocatechin ≥95% (HPLC), from green tea

Sigma-Aldrich

E3768

(−)-Epigallocatechin

(−)-Epigallocatechin analytical standard

Supelco

08108

(−)-Epigallocatechin

(−)-Epigallocatechin phyproof® Reference Substance

PHL89655

(−)-Epigallocatechin

(+)-Catechin phyproof® Reference Substance

PHL89172

(+)-Catechin

Epicatechin primary reference standard

03940590

Epicatechin

Suk-Joon Hyung et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3743-3748 (2013-02-22)
Despite the significance of Alzheimer's disease, the link between metal-associated amyloid-β (metal-Aβ) and disease etiology remains unclear. To elucidate this relationship, chemical tools capable of specifically targeting and modulating metal-Aβ species are necessary, along with a fundamental understanding of their
Angélique Stalmach et al.
Molecular nutrition & food research, 53 Suppl 1, S44-S53 (2008-11-04)
Ten healthy human subjects consumed 500 mL of Choladi green tea, containing 648 mumol of flavan-3-ols after which plasma and urine were collected over a 24 h period and analysed by HPLC-MS. Plasma contained a total of ten metabolites, in
Xiaofeng Meng et al.
Chemical research in toxicology, 15(8), 1042-1050 (2002-08-20)
(-)-Epigallocatechin gallate (EGCG), the most abundant tea catechin, has been proposed to be beneficial to human health based on its strong antioxidative and other biological activities in vitro. Inadequate knowledge regarding the bioavailability and biotransformation of EGCG in humans, however
M Ichihashi et al.
Journal of dermatological science, 23 Suppl 1, S45-S50 (2000-04-15)
Reactive oxygen species (ROS) have been shown to be responsible for inducing DNA damage after ultraviolet radiation (UV). Antioxidant, vitamin E and epigallocatechin gallate extracted from green tea, applied topically to the skin, delayed the onset of UV-induced skin cancer
Masaki Kanadzu et al.
Cancer letters, 241(2), 250-255 (2005-11-24)
(-)-Epigallocatechin gallate (EGCG), a catechin polyphenol component, is the main ingredient of green tea extract. Recently, increasing attention has been given to its anti-oxidant effects. However, several studies reported the oxidative effects of EGCG, suggesting that EGCG had a dual

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