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199508

Sigma-Aldrich

Acridine Yellow G

Dye content 90 %

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About This Item

Empirical Formula (Hill Notation):
C15H15N3 · HCl
CAS Number:
135-49-9
Molecular Weight:
273.76
Colour Index Number:
46025
EC Number:
205-194-2
MDL number:
MFCD00012661
UNSPSC Code:
12171500
PubChem Substance ID:
24851921
NACRES:
NA.47

form

crystalline powder

Quality Level

100

composition

Dye content, 90%

solubility

water: 1 mg/mL, clear, yellow to orange

λmax

442 nm

ε (extinction coefficient)

44000 at 262-268 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cl[H].Cc1cc2cc3cc(C)c(N)cc3nc2cc1N

InChI

1S/C15H15N3.ClH/c1-8-3-10-5-11-4-9(2)13(17)7-15(11)18-14(10)6-12(8)16;/h3-7H,16-17H2,1-2H3;1H

InChI key

BGLGAKMTYHWWKW-UHFFFAOYSA-N

Biochem/physiol Actions

Acridine Yellow G (AYG) is an organic dye with photophysical properties. It is widely used in optics, medicine and photovoltaic cells. AYG has been used as a solar photocatalyst to increase biodegradability and remove ferulic acid, a target pollutant from wastewater. It retards the growth of glioblastoma via dual inhibition of epidermal growth factor receptor and protein kinase c kinases.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCC2837
MKBD9116V
MKBF9403V
MKBF9403
MKBD9116

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G J Tangelder et al.
The American journal of physiology, 268(2 Pt 2), H909-H915 (1995-02-01)
A method is presented to assess in vivo in transparent tissues the leukocyte subtypes that roll in microvessels. In nine rabbits anesthetized with ketamine-xylazine, leukocyte nuclei were stained in situ with acridine yellow (3 mg/kg i.v. for 5 min). Intravital
Kęstutis Aidas et al.
The journal of physical chemistry. B, 117(7), 2069-2080 (2013-01-30)
Attempting to unravel mechanisms in optical probing of proteins, we have performed pilot calculations of two cationic chromophores-acridine yellow and proflavin-located at different binding sites within human serum albumin, including the two primary drug binding sites as well as a
M Teuber et al.
Biochimica et biophysica acta, 1506(1), 31-46 (2001-06-22)
Fluorescent DeltapH and DeltaPsi indicators have been screened for the non-invasive monitoring of bioenergetic processes in whole cells of the cyanobacterium Synechocystis sp. PCC 6803. Acridine yellow and Acridine orange proved to be the best DeltapH indicators for the investigation
T Pérez-Ruíz et al.
Analytical and bioanalytical chemistry, 375(5), 661-665 (2003-03-15)
A flow-injection configuration for the determination of formaldehyde is proposed. The method is based on the enhancing effect of formaldehyde on the oxidation of acridine yellow by bromate in acidic medium. The proposed procedure is simple, inexpensive, sensitive and suitable
Qi Qi et al.
The Journal of biological chemistry, 287(9), 6113-6127 (2012-01-05)
Amplification of the epidermal growth factor receptor (EGFR), frequently expressed as a constitutively active deletion mutant (EGFRvIII), occurs commonly in glioblastoma multiformes (GBM). However, blockade of EGFR is therapeutically disappointing for gliomas with PTEN deletion. To search for small molecules
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