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21192

Supelco

Calcium ionophore I

Selectophore, function tested, ≥99.0%

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Synonym(s):
(−)-(R,R)-N,N′-Bis-[11-(ethoxycarbonyl)undecyl]-N,N′,4,5-tetramethyl-3,6-dioxaoctane-diamide, Diethyl N,N′-[(4R,5R)-4,5-dimethyl-1,8-dioxo-3,6-dioxaoctamethylene]bis(12-methylaminododecanoate), ETH 1001
Empirical Formula (Hill Notation):
C38H72N2O8
CAS Number:
Molecular Weight:
684.99
Beilstein/REAXYS Number:
2343275
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.61

grade

for ion-selective electrodes

Quality Level

product line

Selectophore

assay

≥99.0% (HPLC)
≥99.0%

quality

function tested

SMILES string

CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC

InChI

1S/C38H72N2O8/c1-7-45-37(43)27-23-19-15-11-9-13-17-21-25-29-39(5)35(41)31-47-33(3)34(4)48-32-36(42)40(6)30-26-22-18-14-10-12-16-20-24-28-38(44)46-8-2/h33-34H,7-32H2,1-6H3/t33-,34-/m1/s1

InChI key

CJAONIOAQZUHPN-KKLWWLSJSA-N

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21192

Calcium ionophore I

vibrant-m

21198

Calcium ionophore IV

vibrant-m

21193

Calcium ionophore II

vibrant-m

20909

Cadmium ionophore I

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

grade

for ion-selective electrodes

grade

for ion-selective electrodes

grade

for ion-selective electrodes

grade

for ion-selective electrodes

product line

Selectophore

product line

Selectophore

product line

Selectophore

product line

Selectophore

quality

function tested

quality

function tested

quality

function tested

quality

-

General description

Visit our Sensor Applications portal to learn more.

Application

Selected application examples
Calcium ionophore I (ETH 1001) was used in an experimental study, conducted to determine the intracellular and extracellular changes of calcium ions in hypoxia and ischemia in rat brain.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Used as ionophore in membrane electrodes for the determination of Ca2+-activities; Useful for transport studies in biological membranes

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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I A Silver et al.
The Journal of general physiology, 95(5), 837-866 (1990-05-01)
Changes in intra- and extracellular free calcium concentration were evaluated with ion-selective microelectrodes during periods of anoxia and ischemia in three different regions of intact rat brain. Recordings stable for at least 2 min and in most cases for 4-6
P Caroni et al.
Biochimica et biophysica acta, 470(3), 437-445 (1977-11-01)
The effect of a synthetic neutral ligand on the Ca2+ permeability of several biological membranes has been investigated. The ligand had been previously shown to possess Ca2+ -ionophoric activities in artificial phospholipid membranes. The neutral ionophore is able to transport
Rita I Jabr et al.
Pflugers Archiv : European journal of physiology, 468(11-12), 1945-1955 (2016-10-21)
Cardiac arrhythmias are associated with raised intracellular [Ca2+] and slowed action potential conduction caused by reduced gap junction (GJ) electrical conductance (Gj). Ventricular GJs are composed of connexin proteins (Cx43), with Gj determined by Cx43 phosphorylation status. Connexin phosphorylation is
Anna Kisiel et al.
Talanta, 220, 121358-121358 (2020-09-16)
An alternative optical signal transduction mechanism for ion-selective optodes is proposed. The nanostructural sensors benefit from ion-selective reversing aggregation caused quenching yielding turn-on, bright and highly stable optical signals. Selective incorporation of analyte results in transformation of the polymer dye
W. Simon et al.
Annals of the New York Academy of Sciences, 307, 52-52 (1978)

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